{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T07:44:18Z","timestamp":1695109458562},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\u00dcber die Pr\u00e4valenz von Autoantik\u00f6rpern bei Patienten mit Vitiligo wurde zwar in zahlreichen berichtet belegt, die Ergebnisse waren jedoch bei einigen Autoantik\u00f6rpern nicht konsistent. Ziel der vorliegenden Studie war es, eine systematische \u00dcbersicht \u00fcber die Pr\u00e4valenz von Autoantik\u00f6rpern bei Vitiligo\u2010Patienten zu geben und eine Metaanalyse zu erstellen. Zu diesem Zweck wurde die gesamte Literatur bis zum 31. Dezember 2016 gesichtet. Ber\u00fccksichtigt wurden Fall\u2010Kontroll\u2010Studien mit Vitiligo\u2010Patienten und einer Kontrollgruppe. Bei Vitiligo\u2010Patienten betrug die Pr\u00e4valenz von Anti\u2010Thyreoperoxidase (ATPO)\u2010Antik\u00f6rpern, Anti\u2010Thyreoglobulin (ATG)\u2010Antik\u00f6rpern, antinukle\u00e4ren Antik\u00f6rpern (ANA), Antik\u00f6rpern gegen gastrische Parietalzellen (AGPCA), Antik\u00f6rpern gegen glatte Muskulatur (anti\u2010smooth muscle antibodies, ASMA), antimitochondrialen Antik\u00f6rpern (AMA) und Antik\u00f6rpern gegen die Nebennieren 15,1\u00a0%, 9,7\u00a0%, 12,5\u00a0%, 11,7\u00a0%, 12,6\u00a0%, 0,2\u00a0% beziehungsweise 2,5\u00a0%. Die Pr\u00e4valenz von ATPO\u2010Antik\u00f6rpern (Odds\u2010Ratio [OR]: 3,975; 95\u00a0% Konfidenzintervall [CI]: 3,085\u20135,122), ATG\u2010Antik\u00f6rpern (OR: 3,759, 95\u00a0% CI: 2,554\u20135,531), ANA (OR: 1,797, 95\u00a0% CI: 1,182\u20132,731), AGPCA (OR: 2,503, 95\u00a0% CI: 1,497\u20132,896) und Antik\u00f6rpern gegen die Nebenniere (OR: 9,808, 95\u00a0% CI: 1,809\u201353,159) (Abbildung 2a\u2013e) war bei Vitiligo\u2010Patienten signifikant h\u00f6her als bei der Kontrollgruppe. Patienten mit Vitiligo sollten routinem\u00e4\u00dfig auf Antik\u00f6rper gegen Schilddr\u00fcsenantigene \u00fcberpr\u00fcft werden, um diejenigen Patienten zu ermitteln, bei denen ein hohes Risiko besteht, eine autoimmune Schilddr\u00fcsenerkrankung zu entwickeln.<\/jats:p>","DOI":"10.1111\/ddg.13574_g","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T11:59:05Z","timestamp":1531223945000},"page":"845-853","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitiligo und Autoantik\u00f6rper: Systematischer Review und Metaanalyse"],"prefix":"10.1111","volume":"16","author":[{"given":"Che\u2010Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Cathay General Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Department of Dermatology School of Medicine College of Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)91421-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02089.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11198.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650280028010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.19200"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1993.tb01363.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb01609.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249466"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01712.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.135485"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91889-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.060509"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00408.x"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.13574_g","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.13574_g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T04:20:03Z","timestamp":1695010803000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.13574_g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/ddg.13574_g"],"URL":"https:\/\/doi.org\/10.1111\/ddg.13574_g","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2017-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}