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It usually occurs in areas characterized by a high density of sweat glands such as the axillae and hands. The diagnosis of focal hyperhidrosis is based on history and clinical findings. Supplementary diagnostic tests include gravimetry (measurement of the amount of sweat) and the iodine starch test (which shows the area of sweating). Treatment options consist of topical agents, botulinum toxin\u00a0A injections, iontophoresis, treatment with radiofrequency, microwaves, or ultrasound as well as surgical procedures (axillary suction curettage, sympathectomy). Systemic agents such as anticholinergics may also be used. Selection of the most appropriate therapeutic approach depends on the site affected, prior treatment as well as the patient's requests.<\/jats:p>","DOI":"10.1111\/ddg.13579","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T11:59:05Z","timestamp":1531223945000},"page":"945-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Update of the S1 guidelines on the definition and treatment of primary hyperhidrosis"],"prefix":"10.1111","volume":"16","author":[{"given":"Berthold","family":"Rzany","sequence":"first","affiliation":[{"name":"RZANY &amp; HUND Kurf\u00fcrstendamm 183 10707 Berlin  Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk G.","family":"Bechara","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Dermatochirurgie, Klinik f\u00fcr Dermatologie, Venerologie und Allergologie, Ruhr\u2010Universit\u00e4t Bochum  Bochum Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Feise","sequence":"additional","affiliation":[{"name":"Praxis Dr. Feise, Belegarzt Sophienklinik, Sophienstra\u00dfe 41  70178 Stuttgart Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Praxisklinik f\u00fcr Dermatologie, Kreuzstra\u00dfe 26  82319 Starnberg Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rapprich","sequence":"additional","affiliation":[{"name":"Hautmedizin Bad Soden, Kronberger Stra\u00dfe 2  65812 Bad Soden Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"W\u00f6rle","sequence":"additional","affiliation":[{"name":"Dermatologie und Laserzentrum, Hirslanden Klinik Meggen  Klinik St. Anna AG, Meggen Schweiz"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06334.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.029"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33192.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-008-9261-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153719"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07750_suppl.x"},{"key":"e_1_2_5_10_1","unstructured":"Bundesinstitut f\u00fcr Risikobewertung.Aluminiumhaltige Antitranspirantien tragen zur Aufnahme von Aluminium bei. 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