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Trotz der medizinischen Relevanz der topischen Basistherapie f\u00fcr die Xerosis cutis gibt es in Deutschland f\u00fcr ihr Management bisher keinen wissenschaftlich belegten Diagnostik\u2010 und Therapiealgorithmus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ziel<\/jats:title><jats:p>Dieses Positionspapier vermittelt \u00c4rzten fach\u00fcbergreifend einen an individuellen Symptomen orientierten, praxisnahen Leitfaden f\u00fcr die Pr\u00e4vention, Diagnostik und Therapie der Xerosis cutis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodik<\/jats:title><jats:p>Im Rahmen eines strukturierten Entscheidungsprozesses wurden von erfahrenen dermatologischen Experten zun\u00e4chst praxisrelevante Fragestellungen definiert und systematisch aufgearbeitet. Auf der Basis von Evidenz und Expertenkonsens wurden daraus diagnostische und therapeutische Algorithmen mit Empfehlungen f\u00fcr die Praxis entwickelt und konsentiert.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnis<\/jats:title><jats:p>Die Xerosis cutis kann grunds\u00e4tzlich klinisch diagnostiziert werden. Ausl\u00f6ser und\/oder Grunderkrankungen m\u00fcssen abgekl\u00e4rt und vermieden bzw. spezifisch behandelt werden. Bei der Wahl der geeigneten Basistherapie ist es wichtig, dass nicht nur die Hauthydratation verbessert, sondern auch die Barrierefunktion der Haut wiederhergestellt wird. Sie sollte daher aus einer Kombination von r\u00fcckfeuchtenden und r\u00fcckfettenden Inhaltsstoffen bestehen. Je trockener die Haut, desto lipidhaltiger sollte die Hautpflege sein (bevorzugt Wasser\u2010in\u2010\u00d6l\u2010Formulierungen). Die individuelle Auswahl der Inhaltsstoffe orientiert sich nach kausaler Pr\u00fcfung an den Symptomen Schuppung (v.a. Urea), Fissuren\/Rhagaden (v.a. Urea oder Dexpanthenol), R\u00f6tung (v.a. Licochalcone A) und Pruritus (v.a. Polidocanol), sowie an der Lokalisation und dem Alter der Patienten. Inhaltsstoffe bzw. Inhaltsstoffkombinationen mit guter Studienevidenz sind zu bevorzugen. Die mit Abstand beste Evidenz bei der Xerosis cutis weist Urea auf, dessen Wirksamkeit in Kombination mit anderen nat\u00fcrlichen Feuchthalte\u2010Komponenten und Ceramiden noch gesteigert werden kann. Zur Arbeitserleichterung am Patienten und zum besseren Erlernen wurde das Xerosimeter entwickelt, das die praktische Umsetzung der Diagnostik und Verlaufskontrolle, eine Klassifikation der Inhaltsstoffe und einen strukturierten Therapiealgorithmus enth\u00e4lt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerung<\/jats:title><jats:p>Das hier vorgeschlagene strukturierte symptom\u2010 und evidenzorientierte Vorgehen mit Diagnostik\u2010 und Behandlungspfad soll f\u00fcr die Pr\u00e4vention und fr\u00fchzeitige Behandlung der Xerosis cutis sensibilisieren. Damit k\u00f6nnen die Lebensqualit\u00e4t verbessert und Folgeerkrankungen verhindert werden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13580","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T11:46:03Z","timestamp":1531223163000},"page":"3-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Positionspapier: Diagnostik und Therapie der Xerosis cutis"],"prefix":"10.1111","volume":"16","author":[{"given":"Matthias","family":"Augustin","sequence":"first","affiliation":[{"name":"Universit\u00e4tsklinikum Hamburg\u2010Eppendorf Institut f\u00fcr Versorgungsforschung in der Dermatologie und bei Pflegeberufen (IVDP)  Martinistr. 52 20246 Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Wilsmann\u2010Theis","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie und Allergologie der Rheinischen\u2010Friedrich\u2010Wilhelms Universit\u00e4t Bonn  Sigmund\u2010Freud\u2010Str. 25 53105 Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"K\u00f6rber","sequence":"additional","affiliation":[{"name":"Hautarztpraxis  R\u00fcttenscheider Str.143 45130 Essen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Kerscher","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Hamburg Fachbereich Kosmetikwissenschaft  Papendamm 21 20146 Hamburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6tz","family":"Itschert","sequence":"additional","affiliation":[{"name":"Hautarztpraxis  Am Rathaus 2a 25421 Pinneberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Dippel","sequence":"additional","affiliation":[{"name":"MD medscript &amp; consult  Am Kuhtriftberg 21 67098 Bad D\u00fcrkheim"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Staubach","sequence":"additional","affiliation":[{"name":"Hautklinik und Poliklinik der Universit\u00e4tsmedizin Johannes Gutenberg\u2010Universit\u00e4t  Langenbeckstr. 1 55131 Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"KreskenJ DanielsR Arens\u2010CorellM.Leitlinie der GD Gesellschaft f\u00fcr Dermopharmazie e.V.: Dermokosmetika zur Reinigung und Pflege trockener Haut. 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