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The significance of systemic drugs has been the subject of controversial debate, depending on the underlying cause of the condition. The present review article is therefore meant to highlight current aspects of systemic drug therapies for the treatment of leg ulcers associated with chronic venous insufficiency, peripheral arterial disease, livedoid vasculopathy, vasculitis, necrobiosis lipoidica, calciphylaxis and pyoderma gangrenosum.<\/jats:p><jats:p>In summary, the majority of therapeutic options presented herein are used off\u2010label. While systemic drugs are promising options for the more common types of wounds such as venous, mixed or arterial leg ulcers, they do not represent the current standard of treatment. By contrast, systemic agents play a key role in the management of many of the other disorders presented herein. These agents primarily include immunomodulatory and rheological drugs used to expedite wound healing.<\/jats:p>","DOI":"10.1111\/ddg.13586","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T11:59:05Z","timestamp":1531223945000},"page":"873-890","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Systemic therapies for leg ulcers"],"prefix":"10.1111","volume":"16","author":[{"given":"Joachim","family":"Dissemond","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Erfurt\u2010Berge","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center Erlangen  Erlangen 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