{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:15:52Z","timestamp":1787598952553,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Perifolliculitis capitis abscedens et suffodiens (PCAS; im englischen Sprachraum meist als \u201edissecting folliculitis\u201c oder \u201edissecting cellulitis\u201c bezeichnet) ist eine seltene Krankheit, die mit entstellender vernarbender Alopezie einhergeht. Ziel dieser Studie war es, die Merkmale der PCAS zu untersuchen und eine Klassifikation zur Angabe ihres Schweregrades vorzuschlagen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik<\/jats:title><jats:p>Es wurde eine klinikbasierte retrospektive Studie durchgef\u00fchrt. Patienten, die entweder aufgrund ihres histopathologischen Befundes oder der klinischen Symptomatik als PCAS\u2010Patienten identifiziert wurden, wurden in die Studie eingeschlossen und der Schweregrad ihrer Erkrankungen wurde in eine von drei Stadien eingeteilt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Bei den 66 rekrutierten Patienten (63 M\u00e4nner\/3 Frauen, mittleres Alter 24,9 Jahre) waren mehrere miteinander verbundene haarlose Knoten im Vertexbereich der Kopfhaut das Hauptmerkmal. Histopathologisch zeigte sich ein ausgedehnter entz\u00fcndeter Granulationsabszess, der im akuten Stadium eine Dissektionsfl\u00e4che in der unteren Dermis beziehungsweise Subkutis bildete. Bei sieben von 21 histologischen Proben herrschte eine lymphozyt\u00e4re Infiltration vor. Neunundzwanzig der 45 Patienten waren \u00fcbergewichtig oder adip\u00f6s. Eine Assoziation mit Rauchen wurde nicht beobachtet. Bei 15 der 66 Patienten bestand Komorbidit\u00e4t mit Acne conglobata, zwei davon litten dar\u00fcber hinaus auch an Acne inversa. Eine l\u00e4ngere Krankheitsdauer und eine h\u00f6here Anzahl von Knoten waren mit einem h\u00f6heren Schweregrad der PCAS assoziiert (p &lt; 0,05). Fasst man die unterschiedlichen Therapieformen zusammen, kam es in 25 % der F\u00e4lle zu einer vollst\u00e4ndigen Remission. Betrachtet man ausschlie\u00dflich die Behandlung mit oralem Isotretinoin, betrug die Rate an vollst\u00e4ndigen Remissionen 37,5 %.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Die Perifolliculitis capitis abscedens et suffodiens ist in Taiwan nicht selten. Ein m\u00f6glicher Zusammenhang mit der Adipositas bedarf weiteren Abkl\u00e4rung.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13649_g","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T23:01:20Z","timestamp":1539126080000},"page":"1219-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perifolliculitis capitis abscedens et suffodiens: eine Fallserie mit 66 Patienten und ein Vorschlag zur Klassifikation"],"prefix":"10.1111","volume":"16","author":[{"given":"Chaw\u2010Ning","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenChieh","family":"Chen","sequence":"additional","affiliation":[{"name":"IZZ Immunologie\u2010Zentrum Z\u00fcrich  Z\u00fcrich Schweiz"},{"name":"Klinik und Poliklinik f\u00fcr Dermatologie und Allergologie am Biederstein Technische Universit\u00e4t M\u00fcnchen  M\u00fcnchen Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Kai","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Teng","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Yu\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Cheng Kung University Hospital College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"International Center for Wound Repair and Regeneration National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242207"},{"key":"e_1_2_7_3_1","first-page":"122","article-title":"Perifolliculitis capitis abscedens et suffodiens. 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