{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T07:06:56Z","timestamp":1747379216841},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>This study aimed to compare the efficacy of vitiligo treatments with and without ablation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis of literature published before September 15, 2017. Comparative studies of vitiligo patients treated with and without ablation therapy were included. The primary outcome was \u2265\u00a050\u00a0% repigmentation. Secondary outcomes were \u2265\u00a075\u00a0% repigmentation and patient scores on a subjective visual analogue scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen studies with a total of 401 participants were included. The ablation\u2010based combination therapy group had significantly superior results to the control group (odds ratio [OR] for \u2265\u00a050\u00a0% repigmentation: 10.490, 95\u00a0% confidence interval [CI]: 4.632\u201323.757; OR for \u2265 75\u00a0% repigmentation: 5.812, 95\u00a0% CI: 2.194\u201315.393). Patients receiving ablation\u2010based combination therapy were significantly more satisfied with the efficacy than the control group (standardized mean difference: 1.073, 95\u00a0% CI: 0.528\u20131.619). Subgroup analysis showed that the erbium laser group, CO<jats:sub>2<\/jats:sub> laser group and fractional CO<jats:sub>2<\/jats:sub> laser group achieved significantly better repigmentation than the control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to objective and subjective evaluations, treatments for vitiligo are more effective when combined with ablation therapy than when used alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13657","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T17:23:34Z","timestamp":1537809814000},"page":"1197-1208","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The efficacy of ablation\u2010based combination therapy for vitiligo: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"16","author":[{"given":"Yih\u2010An","family":"King","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung\u2010Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiou\u2010Hsin","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wan Fang Hospital, Taipei Medical University  Taipei Taiwan"},{"name":"Department of Dermatology, School of Medicine, College of Medicine Taipei Medical 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