{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T09:13:16Z","timestamp":1694855596342},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Ziel dieser Studie war ein Vergleich der Wirksamkeit von Vitiligotherapien mit und ohne Ablationverfahren.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Verfahren<\/jats:title><jats:p>Systematische \u00dcbersichtsarbeit und Metaanalyse der vor dem 15. September 2017 publizierten Literatur. Eingeschlossen wurden Vergleichsstudien mit Vitiligopatienten, die mit und ohne Ablationsverfahren behandelt wurden. Prim\u00e4rer Endpunkt der Studie war die Repigmentierung \u2265\u00a050\u00a0%. Sekund\u00e4re Endpunkte waren eine Repigmentierung \u2265\u00a075\u00a0% und Patienten\u2010Scores auf einer subjektiven visuellen Analogskala.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Es wurden f\u00fcnfzehn Studien mit insgesamt 401 Teilnehmern eingeschlossen. Die Gruppe mit ablationsbasierter Kombinationstherapie wies gegen\u00fcber der Kontrollgruppe signifikant bessere Ergebnisse auf (Odds Ratio [OR] bei \u2265\u00a050\u00a0% Repigmentierung: 10,490, 95\u00a0%\u2010Konfidenzintervall [KI]: 4,632\u201323,757; OR bei \u2265\u00a075\u00a0% Repigmentierung: 5,812, 95\u00a0%\u2010KI: 2,194\u201315,393. Patienten, die eine ablationsbasierte Kombinationstherapie erhielten, waren signifikant zufriedener mit der Wirksamkeit als die Kontrollgruppe (standardisierte mittlere Differenz: 1,073, 95\u00a0% KI: 0,528\u20131,619). Eine Subgruppenanalyse zeigte, dass die Erbium\u2010 und die CO<jats:sub>2<\/jats:sub>\u2010Laser\u2010Gruppe sowie die Gruppe mit fraktioniertem CO<jats:sub>2<\/jats:sub>\u2010Laser eine signifikant bessere Repigmentierung als die Kontrollgruppen erreichten.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Sowohl nach objektiven als auch nach subjektiven Kriterien sind Vitiligotherapien in Kombination mit einer Ablationstherapie wirksamer als bei alleiniger Verwendung.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13657_g","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T23:01:20Z","timestamp":1539126080000},"page":"1197-1210","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wirksamkeit einer ablationsbasierten Kombinationstherapie bei Vitiligo: Eine systematische \u00dcbersichtsarbeit und 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