{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:03:30Z","timestamp":1775246610718,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>With an incidence of 1 in 700 births, Down syndrome (DS) is not an uncommon condition. It is associated with various disorders of different organ systems. Serious disorders include cardiac defects and leukemia. With an onset during the newborn period, the latter does not always progress to classic myeloid leukemia (transient myeloproliferative disorder). Skin manifestations in newborns include pustules\/vesiculopustules. In individuals with DS, such lesions should not only prompt suspicion for typical neonatal rashes and infections but also for transient myeloproliferative disorder.<\/jats:p>\n                  <jats:p>However, most dermatoses are benign. They essentially comprise disorders of keratinization that present as xerosis, keratosis pilaris, lichenification, and ichthyosis vulgaris. Also typical but not specific is the four\u2010finger palmar crease (simian crease). Patients frequently develop folliculitides, which \u2013 due to elastolysis \u2013 subsequently progress to anetoderma. The known immune disturbance in DS patients explains the occurrence of autoimmune diseases such as alopecia areata and vitiligo. Typical skin conditions associated with DS include elastosis perforans serpiginosa, syringomas, milia\u2010like calcinosis cutis, and multiple eruptive dermatofibromas.<\/jats:p>","DOI":"10.1111\/ddg.13665","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T19:01:20Z","timestamp":1539111680000},"page":"1289-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dermatological aspects of the S2k guidelines on Down syndrome in childhood and adolescence"],"prefix":"10.1111","volume":"16","author":[{"given":"Regina","family":"F\u00f6lster\u2010Holst","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Schleswig\u2010Holstein University Medical Center Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman","family":"Rohrer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Division of Pediatric Endocrinology and Diabetology Saarland University Medical Center Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u2010Maria","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Division of Pediatric Endocrinology and Diabetology Saarland University Medical Center Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02164.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065859"},{"issue":"2","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D38JX5F2V2","article-title":"Phenotypic and dermatological manifestations in Down Syndrome","volume":"17","author":"Sureshbabu R","year":"2011","journal-title":"Dermatology online journal"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00412.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90354-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515148"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05264-2"},{"issue":"2","key":"e_1_2_8_9_1","first-page":"608","article-title":"Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891","volume":"91","author":"Lange BJ","year":"1998","journal-title":"Blood"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05501.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(72)90130-1"},{"issue":"7","key":"e_1_2_8_12_1","first-page":"569","article-title":"[Pustular diseases of the newborn]","volume":"2","author":"Foelster\u2010Holst R","year":"2004","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","unstructured":"HowardRM FriedenIJ.Neonatal and Infant Dermatology: Vesicles Pustules Bullae Erosions and Ulcerations. 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