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Letztere zeigt sich im Neugeborenenalter und geht nicht immer in eine klassische myeloische Leuk\u00e4mie \u00fcber (transiente myeloproliferative Erkrankung). Dermatologisch bilden die Neugeborenen Pusteln\/Vesikulopusteln, die bei DS nicht nur an typische Neugeborenenexantheme und Infektionen, sondern auch an die transiente myeloproliferative Erkrankung denken lassen sollten.<\/jats:p>\n                  <jats:p>Die meisten Dermatosen jedoch sind benigner Natur und umfassen im Wesentlichen Verhornungsst\u00f6rungen, die sich als Xerosis, Keratosis pilaris, Lichenifikation und Ichthyosis vulgaris zeigen. Typisch, aber nicht spezifisch, ist auch die palmare Vierfingerfurche. Die Patienten neigen h\u00e4ufig zu Follikulitiden, die aufgrund einer Elastolyse in eine Anetodermie \u00fcbergehen. Die bekannte Immundysbalance erkl\u00e4rt das Auftreten von Autoimmunerkrankungen, die sich an der Haut als Alopecia areata und Vitiligo manifestieren. Als typische Hautver\u00e4nderungen bei DS z\u00e4hlen zudem Elastosis perforans serpiginosa, Syringome, Milien\u2010\u00e4hnliche Calcinosis cutis (Milia\u2010like calcinosis cutis) und Multiple eruptive Dermatofibrome.<\/jats:p>","DOI":"10.1111\/ddg.13665_g","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T19:01:20Z","timestamp":1539111680000},"page":"1289-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dermatologische Aspekte aus der S2k\u2010Leitlinie zum Down\u2010Syndrom im Kindes\u2010 und Jugendalter"],"prefix":"10.1111","volume":"16","author":[{"given":"Regina","family":"F\u00f6lster\u2010Holst","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Universit\u00e4tsklinikum Schleswig\u2010Holstein Campus Kiel 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