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Such reactions are primarily due to stings by honeybees (<jats:italic>Apis<\/jats:italic>) and certain social wasps (<jats:italic>Vespula vulgaris<\/jats:italic> and <jats:italic>Vespula germanica<\/jats:italic> in particular). Especially in adults, stings are frequently associated with severe anaphylaxis. Established diagnostic methods including molecular tests allow for greater success rates in terms of determining the insect actually responsible for triggering the anaphylactic reaction. Sensitization to both venoms, or a history of systemic sting reaction without any evidence of sensitization, complicate the decision regarding treatment. Venom immunotherapy (VIT) is a safe and effective causal treatment.<\/jats:p>","DOI":"10.1111\/ddg.13670","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T23:01:20Z","timestamp":1539126080000},"page":"1228-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Honeybee and wasp venom allergy: Sensitization and immunotherapy"],"prefix":"10.1111","volume":"16","author":[{"given":"Hanan","family":"Adib\u2010Tezer","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology Skin Cancer Center Wiesbaden  Helios Dr. Horst Schmidt Clinics Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Bayerl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Skin Cancer Center Wiesbaden  Helios Dr. Horst Schmidt Clinics Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-017-0014-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13262"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-017-0017-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03362543"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91953-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-014-0009-1"},{"key":"e_1_2_8_8_1","first-page":"81","article-title":"Hinweise zur Unterscheidung von Bienen\u2010 und Wespengruppen mit Relevanz f\u00fcr systemische Stichreaktionen in Zentraleuropa","volume":"26","author":"Volker M","year":"2017","journal-title":"Allergo J Int"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-014-2775-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.10.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40629-018-0073-z"},{"key":"e_1_2_8_12_1","first-page":"402","article-title":"Hauttests zur Diagnostik von allergischen Soforttypreaktionen. 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