{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T14:33:53Z","timestamp":1718116433635},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Morphea is frequently associated with other autoimmune disorders. Little is known about the association of morphea and primary biliary cholangitis (PBC). The objective of this case series was to study the possible association of morphea with PBC and to identify risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Patients with morphea were screened for anti\u2010mitochondrial antibodies (AMA) by indirect immunofluorescence and\/or immunoblot. Human leucocyte antigen (HLA) genotyping and deep sequencing for the HLA DRB1 subgroup were confirmed in AMA\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>6 of 91 patients (6.6\u00a0%) showed positivity for AMA, and 4 (4.39\u00a0%) had PBC. The mean age of AMA\u2010positive patients was 69.0 years. Of 6 AMA\u2010positive patients, common predisposing alleles (HLA DRB1*15: 01 and HLA DRB1*08) were detectable in two patients. One patient had predisposing alleles for both diseases (HLA DRB1*03: 01 and HLA DRB1*14). One patient had a PBC\u2010conferring allele. Female gender, menopause and tendency for remission of morphea were common in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The coexistence of morphea, AMA positivity and PBC is a rare but possible association. Common predisposing HLA alleles might interact in such a simultaneous manifestation. We suggest AMA screening for female patients with generalized morphea before the initiation of methotrexate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13693","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T14:22:25Z","timestamp":1541427745000},"page":"1323-1327","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comorbidity of localized scleroderma and primary biliary cholangitis"],"prefix":"10.1111","volume":"16","author":[{"given":"G\u00e1bor","family":"Bali","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Dermato-Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik\u00f3","family":"Szilv\u00e1si","sequence":"additional","affiliation":[{"name":"Hungarian National Blood Transfusion Service Transplantation Immunogenetics Laboratory  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Inotai","sequence":"additional","affiliation":[{"name":"Hungarian National Blood Transfusion Service Transplantation Immunogenetics Laboratory  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Varga","sequence":"additional","affiliation":[{"name":"Hungarian National Blood Transfusion Service Transplantation Immunogenetics Laboratory  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato-Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato-Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato-Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Szegedi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato-Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadett","family":"Hidv\u00e9gi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato-Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.15.24"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7141"},{"key":"e_1_2_7_5_1","first-page":"266","article-title":"Primary biliary cirrhosis and primary sclerosing cholangitis: a review featuring a women\u2019s health perspective","volume":"2","author":"Marchioni Beery RM","year":"2014","journal-title":"J Clin and Transl Hepatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12724"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06311.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8427-x"},{"key":"e_1_2_7_9_1","first-page":"171","article-title":"Localized scleroderma in adults and children. 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