{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:45:44Z","timestamp":1694947544042},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Morphaea ist h\u00e4ufig mit anderen Autoimmunerkrankungen assoziiert. \u00dcber den Zusammenhang zwischen Morphaea und prim\u00e4r bili\u00e4rer Cholangitis (PBC) ist nur wenig bekannt. Das Ziel dieser Fallstudie war die Untersuchung eines m\u00f6glichen Zusammenhangs sowie die Identifizierung der Risikofaktoren.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik<\/jats:title><jats:p>Wir testeten Morphaea\u2010Patienten mittels indirekter Immunfluoreszenz und\/oder Immunblot auf antimitochondriale Antik\u00f6rper (AMA). Bei den AMA\u2010positiven Patienten wurde durch Genotypisierung des Humanen Leukozytenantigens (HLA)\u2010 und Deep Sequencing die HLA DRB1\u2010Untergruppe best\u00e4tigt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Sechs (6,6%) von 91 Patienten waren AMA\u2010positiv, bei 4 (4,39%) lag eine PBC vor. Das Durchschnittsalter der AMA\u2010positiven Patienten lag bei 69,0 Jahren. Bei zwei der 6 AMA\u2010positiven Patienten wurden gemeinsame pr\u00e4disponierende Allele (HLA DRB1*15: 01 und HLA DRB1*08) festgestellt. Ein Patient hatte ein f\u00fcr PBC pr\u00e4disponierendes Allel. Alle Patienten waren weiblich, in der Menopause und zeigten eine Tendenz zur Remission der Morphaea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerung<\/jats:title><jats:p>Die Koexistenz von Morphaea, AMA\u2010Positivit\u00e4t und PBC ist eine seltene, aber m\u00f6gliche Assoziation. Gemeinsame pr\u00e4disponierende HLA\u2010Allele k\u00f6nnten bei einer solchen Manifestation miteinander interagieren. Bei weiblichen Patienten mit generalisierter Morphaea empfehlen wir vor einer Metothrexat\u2010Therapie ein AMA\u2010Screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13693_g","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T14:22:25Z","timestamp":1541427745000},"page":"1323-1328","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Komorbidit\u00e4t von lokalisierter Sklerodermie und prim\u00e4r bili\u00e4rer Cholangitis"],"prefix":"10.1111","volume":"16","author":[{"given":"G\u00e1bor","family":"Bali","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Dermato\u2010Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik\u00f3","family":"Szilv\u00e1si","sequence":"additional","affiliation":[{"name":"Hungarian National Blood Transfusion Service Transplantation Immunogenetics Laboratory  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Inotai","sequence":"additional","affiliation":[{"name":"Hungarian National Blood Transfusion Service Transplantation Immunogenetics Laboratory  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Varga","sequence":"additional","affiliation":[{"name":"Hungarian National Blood Transfusion Service Transplantation Immunogenetics Laboratory  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato\u2010Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato\u2010Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato\u2010Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Szegedi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato\u2010Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadett","family":"Hidv\u00e9gi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Dermato\u2010Oncology Faculty of Medicine Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.1046"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.15.24"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i48.7141"},{"key":"e_1_2_7_5_1","first-page":"266","article-title":"Primary biliary cirrhosis and primary sclerosing cholangitis: a review featuring a women\u2019s health perspective","volume":"2","author":"Marchioni Beery RM","year":"2014","journal-title":"J Clin and Transl Hepatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12724"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06311.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8427-x"},{"key":"e_1_2_7_9_1","first-page":"171","article-title":"Localized scleroderma in adults and children. 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