{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:27:48Z","timestamp":1770715668294,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T00:00:00Z","timestamp":1544486400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Between 2006\u20132010, 84 patients with various types of sarcoma underwent surgery followed by three\u2010dimensional histology. Tumor entities included dermatofibrosarcoma protuberans (DFSP, 54 patients), leiomyosarcoma (ten patients), rhabdomyosarcoma (one patient), angiosarcoma (seven patients) as well as atypical fibroxanthoma (AFX, three patients) and cutaneous undifferentiated pleomorphic sarcoma (UPS, nine patients). Median follow\u2010up was four years (range: 2\u20136 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Local recurrence rates among patients with primary DFSP were 2.2\u00a0%. All patients undergoing re\u2010excision were subsequently tumor free. Patients with leiomyosarcoma, rhabdomyosarcoma, AFX, and cutaneous UPS experienced no local recurrence; however, one individual developed in\u2010transit metastasis (UPS) (8.3\u00a0%). Three patients with angiosarcoma developed local recurrence (43\u00a0%), two of whom remained tumor free following re\u2010excision. Two angiosarcoma patients died from distant metastases (29\u00a0%). Both DFSP and especially angiosarcoma lesions exhibited extensive subclinical growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recurrence rates of cutaneous sarcomas following three\u2010dimensional histology are low. Local recurrences are readily manageable by re\u2010excision. Angiosarcoma is characterized by extensive superficial growth, aggressive biological behavior, and predominantly hematogenous spread.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13708","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T13:16:03Z","timestamp":1544534163000},"page":"1434-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three\u2010dimensional histology"],"prefix":"10.1111","volume":"16","author":[{"given":"Katharina","family":"Welsch","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhardt Karls University  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Breuninger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhardt Karls University  T\u00fcbingen 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