{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T16:34:31Z","timestamp":1722616471501},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Early diagnosis of psoriatic arthritis poses a particular challenge. A novel fluorescence optical imaging technique, the Xiralite\u00ae system is very useful in this regard as it allows for visualization of microvasculature and perfusion. The present study is the first to systematically examine fluorescence optical signals in a large psoriatic arthritis cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>In the primary study, we reviewed and analyzed extra\u2010articular fluorescence optical signal patterns in 241 imaging sequences obtained from 187 psoriatic arthritis patients; 36 fluorescence optical sequences from 31 patients with rheumatoid arthritis served as controls. In a follow\u2010up study, 203 consecutive fluorescence optical sequences from 54 psoriatic arthritis patients and 149 control subjects with various inflammatory rheumatic disorders were retrospectively evaluated in order to validate the primary study results in terms of the patterns previously identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Psoriatic arthritis patients exhibited three different fluorescence optical signal patterns in projection of the nails that have not been previously described. One of these patterns was the \u201cgreen nail\u201d sign, which was highly specific (97\u00a0%) for psoriatic arthritis. In the follow\u2010up study, the specificity of this phenomenon in psoriatic arthritis was 87\u00a0% in comparison to the control cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the present study, fluorescence optical signals in the nail region proved to be highly specific for psoriatic arthritis. The \u201cgreen nail\u201d phenomenon seems to be of particular diagnostic interest as a potential sign of impaired microcirculation of the nail bed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13747","type":"journal-article","created":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T16:29:12Z","timestamp":1548952152000},"page":"138-147","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The \u201cgreen nail\u201d phenomenon in ICG\u2010enhanced fluorescence optical imaging \u2013 a potential tool for the differential diagnosis of psoriatic arthritis"],"prefix":"10.1111","volume":"17","author":[{"given":"Oliver","family":"Wiemann","sequence":"first","affiliation":[{"name":"RHIO (Rheumatology Immunology, Osteology) D\u00fcsseldorf and RHIO Research Institute  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie 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