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By blocking IL\u20104 and IL\u201013 signaling pathways, dupilumab improves both objective signs and subjective symptoms of the disease. Blocking of the IL\u20104aR\u03b1 subunit leads to improvement of the skin's barrier function and reduction in Th2\u2010mediated inflammation. While the rate of adverse events on dupilumab is generally low, mild\u2010to\u2010moderate conjunctivitis associated with redness as well as a burning and foreign body sensation has been reported in up to 28\u00a0% of patients. Treatment options include topical corticosteroids and topical calcineurin inhibitors. The present review highlights the clinical presentation of dupilumab\u2010associated conjunctivitis and addresses pharmacological and non\u2010pharmacological options available for the treatment of this clinically highly relevant condition.<\/jats:p>","DOI":"10.1111\/ddg.13809","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T07:56:54Z","timestamp":1552636614000},"page":"488-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Management of dupilumab\u2010associated conjunctivitis in atopic dermatitis"],"prefix":"10.1111","volume":"17","author":[{"given":"Nora","family":"Aszodi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Thurau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology at Mathildenstra\u00dfe University Medical Center  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Seegr\u00e4ber","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  Munich Germany"},{"name":"Munich City Medical Center Thalkirchner Stra\u00dfe  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein","family":"de Bruin\u2010Weller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Wollenberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  Munich Germany"},{"name":"Munich City Medical Center Thalkirchner Stra\u00dfe  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13599"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14888"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2018.1449642"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16156"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31191-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.036"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.031"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.034"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1700366"},{"key":"e_1_2_6_14_1","volume-title":"Safety of dupilumab in moderate\u2010to\u2010severe atopic dermatitis: clinical laboratory results from the phase 3 clinical trials (LIBERTY AD: SOLO 1, SOLO 2, and CHRONOS)","author":"Wollenberg A","year":"2018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-011-0167-y"},{"key":"e_1_2_6_16_1","first-page":"1","volume-title":"Pharmazeutisches Laboratorium des Neuen Rezeptur\u2010Fomulariums, Standardisierte Rezepturen Formelsammlung f\u00fcr \u00c4rzte. 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