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Disturbances in zinc metabolism may give rise to disorders that typically manifest themselves on the skin. An autosomal recessive zinc deficiency disorder, acrodermatitis enteropathica is caused by a mutation in the gene coding for the ZIP4 transporter. Due to intestinal malabsorption, affected infants develop clinical signs and symptoms shortly after weaning. Acquired zinc deficiency is a rare but underdiagnosed disorder associated with various etiologies and variable clinical manifestations. Depending on the patient's age, a multitude of causes have to be considered. Given the characteristic periorificial and acral lesions, the clinical diagnosis is usually made by dermatologists. Laboratory confirmation includes measurement of plasma zinc levels and \u2013 as a supplementary measure \u2013\u00a0zinc\u2010dependent enzymes such as alkaline phosphatase. Oral zinc replacement therapy frequently leads to clinical remission within a few days. Depending on the cause, disease management should include cooperation with pediatricians and gastroenterologists in order to guarantee optimal patient care.<\/jats:p>","DOI":"10.1111\/ddg.13811","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T08:21:16Z","timestamp":1552638076000},"page":"589-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Zinc and skin: an update"],"prefix":"10.1111","volume":"17","author":[{"given":"Valerie","family":"Glutsch","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center  W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center  W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center  W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.015"},{"key":"e_1_2_15_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/nu10020199","article-title":"Zinc and Skin Disorders","volume":"10","author":"Ogawa Y","year":"2018","journal-title":"Nutrients"},{"key":"e_1_2_15_4_1","first-page":"127","article-title":"Acrodermatitis enteropathica","volume":"23","author":"Danbolt N","year":"1942","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00963-08"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(03)00081-7"},{"key":"e_1_2_15_7_1","doi-asserted-by":"crossref","DOI":"10.1002\/9781118441213.rtd0064","volume-title":"Nutritional Disorders Affecting the Skin","author":"Chu DH","year":"2016"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533615570376"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.06.003"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555560295299"},{"key":"e_1_2_15_11_1","doi-asserted-by":"crossref","DOI":"10.3390\/nu9121286","article-title":"Zinc as a Gatekeeper of Immune Function","volume":"9","author":"Wessels I","year":"2017","journal-title":"Nutrients"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0394632015606845"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2012.03.012"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348263"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11262"},{"key":"e_1_2_15_16_1","article-title":"Clinical utility gene card for: acrodermatitis enteropathica \u2013 update 2015","volume":"24","author":"Kury S","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.028"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.10.003"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328335107f"},{"key":"e_1_2_15_20_1","first-page":"359","article-title":"Zinc deficiency and clinical practice","volume":"47","author":"Yanagisawa H","year":"2004","journal-title":"Japan Medical Association Journal"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.4.883"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32834b3355"},{"key":"e_1_2_15_23_1","first-page":"497","volume-title":"Vitamine, Spurenelemente und Mineralstoffe \u2013 Pr\u00e4vention und Therapie mit Mikron\u00e4hrstoffen","author":"Goebeler M","year":"2002"},{"key":"e_1_2_15_24_1","first-page":"110","article-title":"Dermatitis in children with disturbances of the general condition and the absorption of food elements","volume":"8","author":"Brandt T.","year":"1936","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_15_25_1","first-page":"532","article-title":"Acrodermatitis enteropathica; 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