{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:23:02Z","timestamp":1790270582027,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholinergic urticaria (CholU) is a frequent type of chronic inducible urticaria. Symptomatic treatment with second\u2010generation antihistamines (sgAH) is recommended by current guidelines as first\u2010line therapy, but little is known about how patients with CholU are treated in real life and how they respond to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess real\u2010life treatment of CholU in German\u2010speaking countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CholU (n\u00a0=\u00a0111) took part in an online survey study that assessed their treatments and their treatment responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Virtually all patients (97\u00a0%) had used antihistamines, 87\u00a0% of them sgAH; 23\u00a0% had also taken first\u2010generation antihistamines (fgAH). The proportion of patients who benefited from standard\u2010dosed antihistamine treatment was low (sgAH: 32\u00a0% vs. fgAH: 16\u00a0%), and side effects of sgAH and fgAH were comparable. Updosing of antihistamines had been tried by 66 patients (59\u00a0%) (most commonly [98\u00a0%, n\u00a0=\u00a065] with sgAH) and resulted in marginally better responses (sgAH: 38\u00a0% vs. fgAH: 32\u00a0%). Only very few patients had used other treatments, mostly corticosteroids (30\u00a0%) and omalizumab (5\u00a0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SgAH were commonly used, but insufficient in about two thirds of CholU patients. Accordingly, improved use of third\u2010line and fourth\u2010line treatment options and development of better therapies for patients with CholU are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13979","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T13:53:37Z","timestamp":1574690017000},"page":"1141-1147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Real\u2010life treatment of patients with cholinergic urticaria in German\u2010speaking countries"],"prefix":"10.1111","volume":"17","author":[{"given":"Emilia","family":"Mellerowicz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Weller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Charit\u00e9 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