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All subtypes are typically seen in the later decades of life, although all histologic subtypes have been described in women younger than 30 years. The diagnosis is often delayed. Exact mapping of biopsies is of high importance, as the location and distance from the midline guides the surgical approach depending on the underlying histology. Squamous cell carcinoma accounts for more than 76\u00a0% of vulvar cancer with vulvar intraepithelial neoplasia being an important precursor. Basal cell carcinoma is the second most common vulvar malignancy. Melanoma accounts for 5.7\u00a0% of vulvar cancer and has a worse prognosis compared to cutaneous melanoma. Most of the trials on checkpoint inhibitors and targeted therapy have not excluded patients with vulvar melanoma and the preliminary evidence is reviewed in the manuscript.<\/jats:p><jats:p>Surgery remains the primary treatment modality of locally resectable vulvar cancer. In view of the rarity, the procedure should be performed in dedicated cancer centers to achieve optimal disease control and maintain continence and sexual function whenever possible.<\/jats:p>","DOI":"10.1111\/ddg.13995","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T11:44:17Z","timestamp":1576151057000},"page":"1257-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Vulvar malignancies: an interdisciplinary perspective"],"prefix":"10.1111","volume":"17","author":[{"given":"Christoph","family":"Wohlmuth","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Paracelsus Medical University  Salzburg Austria"},{"name":"Division of Gynecologic Oncology Department of Surgical Oncology University Health Network  Toronto ON Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto  ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Wohlmuth\u2010Wieser","sequence":"additional","affiliation":[{"name":"Department of Dermatology Paracelsus Medical University Salzburg  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,12]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Gray's Anatomy: The Anatomical Basis of Clinical Practice","author":"Stranding S","year":"2015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_10_4_1","unstructured":"ECIS \u2013 European Cancer Information System [Internet]. 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