{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:19:56Z","timestamp":1789233596702,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Placebo effects are used in the treatment of various medical conditions. To date, there is little scientific data in this regard as it relates to skin diseases in general and hardly any data with respect to wound healing in particular.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In a prospective randomized controlled trial, patients with chronic venous leg ulcers were observed for a period of 14 weeks. The objective was to investigate whether raising patients\u2019 expectations with regard to a novel wound treatment might have an effect on wound healing processes as well as wound\u2010related quality of life, anxiety, depression and pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 20 patients were included in the trial. They were stratified based on gender and randomized to either the intervention (IG) or the control group (CG). In both groups, the wound area decreased significantly over the course of the observation period. Unlike patients in the CG, those in the IG experienced significant improvement in wound\u2010related quality of life (wound\u2010QoL) in terms of both the overall score and the various subscales. Neither group showed significant changes with respect to pain, anxiety and depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study is the first to show that \u2013\u00a0merely by raising patients\u2019 expectations for a novel treatment \u2013\u00a0placebo effects can significantly improve quality of life in patients with chronic venous leg ulcers. In the future, our findings should be integrated into the development of treatment concepts for patients with chronic wounds and should be investigated in larger cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.13996","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T09:12:48Z","timestamp":1575882768000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of placebo effects on quality of life and wound healing in patients with chronic venous leg ulcers"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-5101","authenticated-orcid":false,"given":"Finja","family":"Jockenh\u00f6fer","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Knust","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Benson","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Medical Center  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Schedlowski","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Behavioral Immunobiology University Medical Center  Essen Germany"},{"name":"Department of Clinical Neuroscience Osher Center for Integrative Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3893-328X","authenticated-orcid":false,"given":"Joachim","family":"Dissemond","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Center  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-016-3761-y"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.06052.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92899-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1571"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181cbd38b"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3923"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009423"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3976"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243374"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13158"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126074"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079576"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2018.01.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1027\/2151-2604\/a000183"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.522"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12193"},{"key":"e_1_2_6_18_1","article-title":"Hospital anxiety and depression scale \u2013 German Version. 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