{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:10:11Z","timestamp":1783437011800,"version":"3.54.6"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Actinic keratoses (AKs) are common lesions in light\u2010skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence\u2010based framework for clinical decision making, the guidelines for actinic keratosis and cutaneous squamous cell carcinoma were developed using the highest level of methodology (S3) according to regulations issued by the Association of Scientific Medical Societies in Germany (AWMF). The guidelines are aimed at dermatologists, general practitioners, ENT specialists, surgeons, oncologists, radiologists and radiation oncologists in hospitals and office\u2010based settings as well as other medical specialties involved in the diagnosis and treatment of patients with AKs and cSCC. The guidelines are also aimed at affected patients, their relatives, policy makers and insurance funds. In the second part, we will address aspects relating to epidemiology, etiology, surgical and systemic treatment of cSCC, follow\u2010up and disease prevention, and discuss AKs and cSCC in the context of occupational disease regulations.<\/jats:p>","DOI":"10.1111\/ddg.14072","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T21:16:43Z","timestamp":1586035003000},"page":"400-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["S3 guideline for actinic keratosis and cutaneous squamous cell carcinoma (cSCC) \u2013 short version, part 2: epidemiology, surgical and systemic treatment of cSCC, follow\u2010up, prevention and occupational disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Ulrike","family":"Leiter","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus V.","family":"Heppt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  LMU Munich Munich Germany"},{"name":"Department of Dermatology Friedrich Alexander University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Steeb","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  LMU Munich Munich Germany"},{"name":"Department of Dermatology Friedrich Alexander University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Carl Gustav Carus University Medical Center  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen C.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Essen University Medical Center  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhardt","family":"Breitbart","sequence":"additional","affiliation":[{"name":"Skin Cancer Center Elbe Medical Center  Buxtehude Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Breuninger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Institute for Clinical Social Medicine Heidelberg University Medical Center  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dirschka","sequence":"additional","affiliation":[{"name":"CentroDerm Clinic and Medical Faculty of Witten Herdecke University  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eigentler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Flaig","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  LMU Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Follmann","sequence":"additional","affiliation":[{"name":"German Cancer Society  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Fritz","sequence":"additional","affiliation":[{"name":"Dermatology and Laser Center  Landau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Greinert","sequence":"additional","affiliation":[{"name":"Skin Cancer Center Elbe Medical Center  Buxtehude Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Gutzmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Hanover Medical School  Hanover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hillen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Vivantes Medical Center  Berlin\u2010Neuk\u00f6lln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Ihrler","sequence":"additional","affiliation":[{"name":"Dermpath  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swen Malte","family":"John","sequence":"additional","affiliation":[{"name":"Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"K\u00f6lbl","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Regensburg University Medical Center  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kraywinkel","sequence":"additional","affiliation":[{"name":"Robert Koch Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"L\u00f6ser","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ludwigshafen Medical Center  Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Nashan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dortmund Medical Center  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Noor","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Nothacker","sequence":"additional","affiliation":[{"name":"Association of Scientific Medical Societies in Germany (AWMF)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Pfannenberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Medical Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Salavastru","sequence":"additional","affiliation":[{"name":"Dermatology and Laser Center  Landau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruhr University of Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eggert","family":"Stockfleth","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruhr University of Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf\u2010Markus","family":"Szeimies","sequence":"additional","affiliation":[{"name":"Department of Dermatology Knappschaftskrankenhaus Recklinghausen  Recklinghausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claas","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology Charit\u00e9 University Medical Center  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Welzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wermker","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Osnabr\u00fcck Medical Center  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Garbe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Berking","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Medical Center  LMU Munich Munich Germany"},{"name":"Department of Dermatology Friedrich Alexander University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13222"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05554.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77574-6_8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13508"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.03.039"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.110"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000488"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-016-3875-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13577"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33087.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000554"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.7.751"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10079"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.06.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2003.08.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079089"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2006.06.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.03.009"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2612"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23684"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24692"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1700-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24580"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.025"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000158349.64337.ED"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01095.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23982"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22509"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2005.01496.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20608"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21965"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.06.399"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.05.001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/ddg.12583","article-title":"Electrochemotherapy in advanced skin tumors and cutaneous metastases \u2013 a retrospective multicenter analysis","volume":"13","author":"Kreuter A","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805131"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02997.x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04004.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204166"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.6376"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990209)80:4<511::AID-IJC5>3.0.CO;2-P"},{"key":"e_1_2_9_43_1","unstructured":"Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK AWMF): S3\u2010Leitlinie Pr\u00e4vention von Hautkrebs Langversion 1.1 2014 AWMF\u2010Register.\u2010Nr.: 032\/052OL. Available from:https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/032\u2010052OL.html[Last accessed May 28 2018]."}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fddg.14072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.14072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ddg.14072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.14072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:07:57Z","timestamp":1694048877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.14072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/ddg.14072"],"URL":"https:\/\/doi.org\/10.1111\/ddg.14072","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2020-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}