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F\u00fcr die Definition der Krankheitsbilder sind demnach die Morphe der Einzell\u00e4sionen und das Verteilungsmuster entscheidend. \u00c4tiopathogenetisch liegt dem EEM in der \u00fcberwiegenden Zahl der F\u00e4lle eine Infektion (vor allem mit dem Herpes\u2010simplex\u2010Virus oder<jats:italic>Mycoplasma pneumoniae<\/jats:italic>), SJS\/TEN jedoch meist eine Arzneimittelreaktion zugrunde. Die Prognoseeinsch\u00e4tzung im Falle einer SJS\/TEN\u2010Erkrankung kann und sollte anhand des SCORTEN (Score of toxic epidermal necrolysis) erfolgen.<\/jats:p><jats:p>W\u00e4hrend f\u00fcr EEM eine supportive Therapie allgemein als ausreichend angesehen wird, besteht \u00fcber die systemische Therapie der schwerer verlaufenden SJS\/TEN\u2010Erkrankungen weiterhin Unklarheit. Aufgrund fehlender hochqualitativer Therapiestudien und teilweise widerspr\u00fcchlicher Ergebnisse k\u00f6nnen aktuell keine eindeutigen Empfehlungen f\u00fcr eine immunmodulierende Therapie gegeben werden. Einem raschen immunsuppressiven Effekt steht prinzipiell ein erh\u00f6htes Infektionsrisiko gegen\u00fcber. Vor allem f\u00fcr Ciclosporin mehren sich allerdings Hinweise, dass es das Fortschreiten der Hautabl\u00f6sung stoppen und die Letalit\u00e4t von SJS\/TEN senken kann.<\/jats:p><jats:p>Unterst\u00fctzung bei der Diagnostik und Therapie dieser Krankheitsentit\u00e4ten kann vom Dokumentationszentrum schwerer Hautreaktionen (dZh) an der Universit\u00e4tsklinik f\u00fcr Dermatologie Freiburg eingeholt werden.<\/jats:p>","DOI":"10.1111\/ddg.14118_g","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T07:17:46Z","timestamp":1591773466000},"page":"547-553","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Erythema exsudativum multiforme, Stevens\u2010Johnson\u2010Syndrom\/toxische epidermale Nekrolyse \u2013 Diagnostik und Therapie"],"prefix":"10.1111","volume":"18","author":[{"given":"Pavel","family":"Gr\u00fcnwald","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie und Venerologie Universit\u00e4tsmedizin Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Mockenhaupt","sequence":"additional","affiliation":[{"name":"Dokumentationszentrum schwerer Hautreaktionen (dZh) Klinik f\u00fcr Dermatologie und Venerologie Universit\u00e4tsklinikum Freiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Panzer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie und Venerologie Universit\u00e4tsmedizin Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Emmert","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Dermatologie und Venerologie Universit\u00e4tsmedizin Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"e_1_2_6_2_1","article-title":"Acute Exantheme und Hautkrankheiten, Verlag von Ferdinand von Enke","author":"Hebra F","year":"1860","journal-title":"Erlangen"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1136\/bmj.1.4667.1393"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1001\/archderm.1993.01680220104023"},{"volume-title":"Fitzpatrick's dermatology","year":"2019","author":"Mockenhaupt M","key":"e_1_2_6_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/jdv.13352"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1046\/j.1365-2133.1996.d01-924.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.5772\/22335"},{"key":"e_1_2_6_10_1","first-page":"332","volume-title":"Dermatology","author":"H\u00f6tzenecker W","year":"2018"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1111\/bjd.12133"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1038\/sj.jid.5701033"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1016\/j.jaip.2017.11.023"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.2147\/CMAR.S163391"},{"unstructured":"AWMF\u2010S3\u2010Leitlinie.Durchf\u00fchrung des Epikutantests mit Kontaktallergenen und Arzneimitteln.2019. 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