{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:27:24Z","timestamp":1778902044955,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T00:00:00Z","timestamp":1594512000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The melanin fluorescence of skin lesions is measurable with two\u2010photon excitation, a process termed dermatofluoroscopy, which has shown a shift from the green spectra in benign melanocytic lesions to the red spectra in melanoma. This study addressed the question as to which kind of pigmented lesions can be correctly diagnosed as melanin\u2010bearing malignant tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>476 pigmented lesions including 101 cutaneous melanomas were analyzed with dermatofluoroscopy, measuring the melanin fluorescence in a grid\u2010like fashion with a separation of measurement points of 0.2\u00a0mm. The results of the dermatofluoroscopy are presented as a diagnostic score with a cut\u2010off score of \u2265\u00a028 for the diagnosis of melanin\u2010bearing malignant tumors, and were compared to the gold standard of histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A highly significant difference (p\u00a0&lt;\u00a00.0001) between the diagnostic scores of different skin tumors was found. Dermatofluoroscopy scores showed the highest sensitivity for melanomas (92.1\u00a0%). Interestingly, most pigmented basal cell carcinomas (BCCs, 88.9\u00a0%) were diagnosed as melanin\u2010bearing malignant tumors. A higher sensitivity for the correct diagnosis was observed in older patients (\u2265\u00a053 years, p\u00a0=\u00a00.003), in patients with skin tanning (p\u00a0=\u00a00.025), and in patients with freckles during childhood (p\u00a0=\u00a00.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two\u2010photon fluorescence is an innovative technique for the diagnosis of pigmented skin lesions, and shows a high sensitivity for detection of melanomas and pigmented BCCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14163","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T05:45:38Z","timestamp":1594619138000},"page":"682-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dermatofluoroscopy diagnostics in different pigmented skin lesions: Strengths and weaknesses"],"prefix":"10.1111","volume":"18","author":[{"given":"Maja Ann","family":"Hofmann","sequence":"first","affiliation":[{"name":"University Department of Dermatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Keim","sequence":"additional","affiliation":[{"name":"Center of Dermatooncology Department of Dermatology Eberhard Karls University  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Jagoda","sequence":"additional","affiliation":[{"name":"University Department of Dermatology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Forschner","sequence":"additional","affiliation":[{"name":"Center of Dermatooncology Department of Dermatology Eberhard Karls University  T\u00fcbingen 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