{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:22:31Z","timestamp":1787160151738,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Cutaneous polyarteritis nodosa (CPAN) is a comparatively rare form of vasculitis that affects small arteries and arterioles in the panniculus and dermo\u2010subcutaneous junction. Limited information is available regarding its course in the European population. The aim of this study is to characterize the manifestations and prognostic markers of recurrence in CPAN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We report a retrospective study of patients with clinical and histopathologic evidence of CPAN, which was treated at two tertiary referral centers in Spain between 1989 and 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>31 patients were included. The most frequent manifestation was subcutaneous nodules (90.3\u00a0%); ulcers were frequent at diagnosis (35.5\u00a0%). Two thirds of the patients had at least one extracutaneous manifestation. Seventeen patients (54.8\u00a0%) experienced relapse. The strongest predictor of recurrence was ulceration in the initial episode (OR 18.6; 95\u00a0% CI 2.73\u201338; p\u00a0&lt;\u00a00.01). The pre\u2010treatment results of laboratory parameters associated with inflammation (such as C\u2010reactive protein and neutrophil\u2010to\u2010lymphocyte ratio) were significantly higher in the relapsing group. There were no disease\u2010related deaths and none of the patients developed systemic PAN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although CPAN is a vasculitis limited to the skin, symptoms may involve adjacent skeletal muscle or peripheral nerves. While the condition is not life\u2010threatening, the presence of ulceration and elevation of certain laboratory parameters predicts a worse prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.14271","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T02:01:10Z","timestamp":1601863270000},"page":"1250-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa"],"prefix":"10.1111","volume":"18","author":[{"given":"M\u00f3nica","family":"Munera\u2010Campos","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona  Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Bielsa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona  Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Mart\u00ednez\u2010Morillo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hospital Universitari Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona  Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Vall d\u2019Hebron Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Oliv\u00e9","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hospital Universitari Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona  Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ferr\u00e1ndiz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol Universitat Aut\u00f2noma de Barcelona  Badalona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08725.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8612-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/ddg.12859","article-title":"Vasculitic wheel \u2013 an algorithmic approach to cutaneous vasculitides","volume":"13","author":"Ratzinger G","year":"2015","journal-title":"J. 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