{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:08:12Z","timestamp":1782234492425,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between <jats:italic>Borrelia burgdorferi<\/jats:italic> and primary cutaneous lymphoma is still unclear. This systematic review and meta\u2010analysis aims to define the association of <jats:italic>Borrelia burgdorferi<\/jats:italic> with primary cutaneous lymphoma and its different entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases were searched for all studies that assessed the presence of <jats:italic>Borrelia burgdorferi<\/jats:italic> DNA in specimens of primary cutaneous lymphoma. The association between <jats:italic>Borrelia<\/jats:italic> and primary cutaneous lymphomas was assessed with an odds ratio (significant p\u00a0&lt;\u00a00.05); cutaneous specimens with no lymphoproliferative disorders were used as controls. A secondary analysis was performed to assess the prevalence of <jats:italic>Borrelia<\/jats:italic> infection in different lymphoma entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies with 506 primary cutaneous lymphomas and 201 controls were included. The prevalence of <jats:italic>Borrelia<\/jats:italic> DNA positivity was highly heterogeneous among studies from different regions. <jats:italic>Borrelia<\/jats:italic> DNA positivity was significantly associated with primary cutaneous lymphomas (odds ratio = 10.88; p\u00a0&lt;\u00a00.00001). The prevalence of <jats:italic>Borrelia<\/jats:italic> DNA positivity was similar among different entities (marginal zone: 7.3\u00a0%; follicular: 8.1\u00a0%; diffuse large B\u2010cell: 7.5\u00a0%; mycosis fungoides: 8\u00a0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Borrelia burgdorferi<\/jats:italic> is significantly associated with primary cutaneous lymphomas, with no differences among the several lymphoma entities (both B\u2010cell and T\u2010cell), but with strong geographical differences. Molecular testing for <jats:italic>Borrelia<\/jats:italic> would be justified in patients with primary cutaneous lymphoma from endemic areas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14289","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T08:18:45Z","timestamp":1602145125000},"page":"1379-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Borrelia burgdorferi<\/i> in primary cutaneous lymphomas: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"18","author":[{"given":"Antonio","family":"Travaglino","sequence":"first","affiliation":[{"name":"Pathology Section Department of Advanced Biomedical Sciences University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Varricchio","sequence":"additional","affiliation":[{"name":"Pathology Section Department of Advanced 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