{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:49:08Z","timestamp":1694119748910},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele:<\/jats:title><jats:p>Die Lichturtikaria ist eine seltene Photodermatose, deren Diagnostik und Therapie bisher nicht vereinheitlicht ist. Ziel dieser Arbeit war es, innovative Strahlenquellen zur Diagnostik zu verwenden, deren Emissionsspektren und Dosen definiert und reproduzierbar sind, sowie ein einheitliches Therapiestufenschema zu entwickeln.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik:<\/jats:title><jats:p>In einer longitudinalen Studie wurden 27 Patienten mit Lichturtikaria \u00fcber 13 Jahre untersucht. Bei charakteristischer Anamnese erfolgte die Diagnosesicherung mit Photoprovokationen durch verschiedene Strahlenquellen (UVB, UVB311nm, UVA, UVA1, Gr\u00fcnlich, Rotlicht) sowie ein Therapiestufenschema aus Lichtschutz, Antihistaminika, <jats:italic>Rush\u2010Hardening<\/jats:italic> mit UVA\u20101 sowie die Gabe von Omalizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse:<\/jats:title><jats:p>Aktionsspektren: UVB 44\u00a0%, UVA 70\u00a0%, UVA1 89\u00a0%, Gr\u00fcnlicht 37\u00a0% und 22\u00a0% Rotlicht. Bei 20 Patienten wurde ein <jats:italic>Rush\u2010Hardening<\/jats:italic> mit anschlie\u00dfender Erhaltungstherapie durchgef\u00fchrt, wobei 17 hierdurch ausreichend gesch\u00fctzt waren. Bei drei weiteren wurde zus\u00e4tzlich Omalizumab verabreicht.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen:<\/jats:title><jats:p>Die Photoprovokation mit UVB, UVB311nm, UVA, UVA\u20101 und sichtbarem Licht ist in jeder Hautklinik mit einer Lichtabteilung einheitlich m\u00f6glich. Anhand des Therapiestufenschemas k\u00f6nnen die Patienten gut eingestellt werden. Ein Rush\u2010Hardening mit dem UVA\u20101\u2010Metallhalogenstrahler mit konsekutiver Erhaltungstherapie ist eine sichere Methode, der Mehrheit der Patienten \u00fcber die sonnenreiche Jahreszeit zu helfen. Bei unzureichender Effektivit\u00e4t ist Omalizumab eine weitere Therapieoption mit guter Wirksamkeit, die momentan nur im Off\u2010label\u2010Use m\u00f6glich ist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14309_g","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T08:43:18Z","timestamp":1606725798000},"page":"1261-1269","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lichturtikaria: Klinik, Diagnostik, Verlauf und Therapiemanagement bei 27 Patienten"],"prefix":"10.1111","volume":"18","author":[{"given":"Noemi","family":"Gaebelein\u2010Wissing","sequence":"first","affiliation":[{"name":"Zentrums f\u00fcr Dermatologie HELIOS Universit\u00e4tsklinikum Wuppertal Universit\u00e4t Witten\u2010Herdecke  Wuppertal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Ellenbogen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine University of Tel Aviv  Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Percy","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Zentrums f\u00fcr Dermatologie HELIOS Universit\u00e4tsklinikum Wuppertal Universit\u00e4t Witten\u2010Herdecke  Wuppertal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"issue":"12","key":"e_1_2_7_2_1","first-page":"1250","article-title":"Solar urticaria","volume":"13","author":"Goetze S","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-12686-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/AC.2000.6347"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.9.1149"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.1933"},{"key":"e_1_2_7_7_1","first-page":"262","article-title":"Solar urticaria in 145 patients: assessment of action spectra and impact on quality of life in adults and children. 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