{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T10:47:23Z","timestamp":1693306043841},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Zielsetzungen<\/jats:title><jats:p>Bei Patienten mit ausgedehnter Vitiligo wurden verschiedene Methoden zur Entfernung der Restpigmentierung im Gesicht angewendet. Es gibt jedoch nach wie vor kein ideales Depigmentierungsmittel. K\u00fcrzlich wurde \u00fcber die Verwendung von Trichloressigs\u00e4ure (TCA) zur Depigmentierung bei universeller Vitiligo berichtet. Unser Ziel ist die Pr\u00fcfung der Wirksamkeit und Sicherheit von 100\u00a0% TCA zur Depigmentierung bei therapieresistenter Gesichtspigmentierung bei Patienten mit universeller Vitiligo in \u00c4gypten.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methoden<\/jats:title><jats:p>Die Studie umfasste 50\u00a0Patienten mit universeller Vitiligo und Restpigmentierung im Gesicht, die psychische Belastungen verursachte. Trichloressigs\u00e4ure wurde in einer Konzentration von 100\u00a0% fokal auf die pigmentierten Stellen aufgetragen. Die Behandlung wurde alle zwei Wochen bis zur vollst\u00e4ndigen Depigmentierung oder in maximal f\u00fcnf Behandlungssitzungen wiederholt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Bei 80\u00a0% der untersuchten F\u00e4lle war das Ansprechen auf die TCA\u2010Behandlung ausgezeichnet (&gt;\u00a090\u00a0% Depigmentierung). Bei 12\u00a0% lag ein partielles Ansprechen (50\u201390\u00a0% Depigmentierung) vor, und bei 8\u00a0% war das Ansprechen unzureichend (&lt;\u00a050\u00a0% Depigmentierung). Es traten geringf\u00fcgige unerw\u00fcnschte Wirkungen wie Brennen, Erosionen und lokale Infektionen auf.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Trichloressigs\u00e4ure scheint eine kosteng\u00fcnstige und gut vertr\u00e4gliche Therapieoption zur Behandlung therapieresistenter Restpigmentierungen bei Patienten mit ausgedehnter Vitiligo zu sein. Die Behandlung ist mit k\u00fcrzeren Ausfallzeiten und minimalen Nebenwirkungen verbunden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14316_g","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T03:32:19Z","timestamp":1613619139000},"page":"241-247","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Die Verwendung von Trichloressigs\u00e4ure als Depigmentierungstherapie bei Vitiligo universalis"],"prefix":"10.1111","volume":"19","author":[{"given":"Ahmad","family":"Nofal","sequence":"first","affiliation":[{"name":"Dermatology Venereology and Andrology Department Faculty of Medicine Zagazig University  Zagazig Egypt"},{"name":"Member of Interactive Dermatology Research Foundation  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Dermatology Venereology and Andrology Department Faculty 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