{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:21Z","timestamp":1791938721496,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Aberrant tissue expression of matrix metalloproteinases has been observed in acne. Our objective was to study the relevance of <jats:italic>MMP\u20102 (\u20101306 C\/T, rs243865)<\/jats:italic> and <jats:italic>TIMP\u20102 (\u2010418 G\/C, rs8179090)<\/jats:italic> single nucleotide polymorphisms (SNP) in acne and post\u2010acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>512 patients (169 having acne without scarring, 319 having atrophic acne scarring, 24 having hypertrophic acne scarring) and 161 age\u2010matched controls were recruited from the Dermatology Outpatient Department after obtaining informed written consent. Venous blood (5 ml) was collected for genotyping by Polymerase Chain Reaction (PCR)\u2010Restriction Fragment Length Polymorphism (RFLP) method. The severity of acne and acne\u2010scarring were graded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Males had a significantly increased risk of developing severe acne (<jats:italic>P<\/jats:italic> = 0.012), extra\u2010facial acne (<jats:italic>P<\/jats:italic> = 0.047) and extra\u2010facial acne scarring (<jats:italic>P<\/jats:italic> = 0.0001). The presence of inflammatory acne positively correlated with severity of scarring (<jats:italic>P<\/jats:italic> = 0.001). Subjects with a homozygous CC genotype of <jats:italic>MMP\u20102 (\u20101306 C\/T)<\/jats:italic> had 1.0, 7.8 and 8.2 times the odds of developing hypertrophic scarring when compared to controls (<jats:italic>P<\/jats:italic> = 0.05, 95\u00a0% CI: 0.7\u20131.6), subjects having acne without scarring (<jats:italic>P<\/jats:italic> = 0.047, 95\u00a0% CI: 1.0\u201359.9) and subjects having atrophic scarring, respectively (<jats:italic>P<\/jats:italic> = 0.041, 95\u00a0% CI: 1.1\u201359.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant association was observed between hypertrophic post\u2010acne scarring and the CC genotype of <jats:italic>MMP\u20102 (\u20101306 C\/T)<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14338","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T23:48:21Z","timestamp":1609285701000},"page":"1426-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hypertrophic post\u2010acne scarring is associated with a single nucleotide polymorphism (rs243865) in the <i>matrix metalloproteinase\u20102<\/i> gene"],"prefix":"10.1111","volume":"18","author":[{"given":"Navya","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Bishnoi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Leprology Postgraduate Institute of Medical Education and Research  Chandigarh 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Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipankar","family":"De","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Leprology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research  Chandigarh 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