{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:28:17Z","timestamp":1770330497055,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association of atopic dermatitis (AD) and allergic contact dermatitis has been a matter of considerable uncertainty. Study results range from lack of any association to increased sensitization for multiple allergens, but fail to identify consistent allergen associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We studied a large patch test cohort of patients stratified by their atopic skin diathesis using the Erlangen Atopy Score (EAS), independent of active skin disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective multi\u2010center data analysis from five departments of dermatology in Germany with 4,509 patients. Patients were grouped as \u201cno atopic skin diathesis\u201d (n\u00a0=\u00a02,165) and \u201catopic skin diathesis\u201d (n\u00a0=\u00a01,743), according to EAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly more individuals with atopic skin diathesis showed at least one positive patch test reaction to the baseline series compared to individuals without atopic skin diathesis (49.1\u00a0% vs. 38.3\u00a0%). In logistic regression analyses, atopic skin diathesis was associated with a significantly higher risk of sensitization to methylchloroisothiazolinone\/methylisothiazolinone (OR 2.383) and methylisothiazolinone (OR 1.891), thiuram mix (OR 1.614), as well as nickel (OR 1.530), cobalt (OR 1.683), and chromium (OR 2.089).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atopic skin diathesis proved to be the most important intrinsic risk factor for contact sensitization to few, specific allergens. Past or present AD was a less relevant variable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14341","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T03:32:19Z","timestamp":1613619139000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies"],"prefix":"10.1111","volume":"19","author":[{"given":"Susann","family":"Forkel","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Centre G\u00f6ttingen  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naciye","family":"Cevik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Medical Centre G\u00f6ttingen  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