{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:40:30Z","timestamp":1784198430685,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin protection products, formerly named as barrier creams, are being used as primary and secondary prevention measures against occupational dermatoses. Many of these cosmetic products are claimed by manufacturers to be efficacious against wet work\u2010induced skin barrier impairment if applied prior to exposure. However, results of validated and standardized <jats:italic>in vivo<\/jats:italic> efficacy tests allowing the comparison of different products are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Efficacy of six skin protection products against sodium lauryl sulphate\u2010induced irritant contact dermatitis was investigated in a double blind, randomized and controlled repetitive irritation study in healthy volunteers using skin physiological methods. Transepidermal water loss (TEWL) results were used to calculate an efficacy index of protection by mathematical\/statistical means according to a protocol developed in a German Statutory Accident Insurance (DGUV) multicenter study (research project FP 275).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All tested products had a demonstrable, protective effect against SLS compared to controls, but their relative efficacy varied significantly. Differences were also seen upon evaluation of other parameters such as corneometry and clinical irritation score (visual score).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Product ranking as a result of the established differences allows improved selection of appropriate skin protection products based on objective parameters, as compared to heterogenous product claims.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14359","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T06:14:57Z","timestamp":1616739297000},"page":"545-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Double blind randomized repetitive efficacy test of various occupational skin protection preparations against sodium lauryl sulphate"],"prefix":"10.1111","volume":"19","author":[{"given":"Sibylle","family":"Schliemann","sequence":"first","affiliation":[{"name":"Department of Dermatology Jena University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Health Protection Prevention Division Employer\u2019s Liability Insurance Association for the Food and Hospitality Sector (BGN)  Erfurt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Stadeler","sequence":"additional","affiliation":[{"name":"Department of Health Protection Prevention Division Employer\u2019s Liability Insurance Association for the Food and Hospitality Sector (BGN)  Erfurt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Elsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jena University Medical 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