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In this review, we summarize reported cases of ichthyosis with fungal infection over the past 50 years. Atypical manifestations such as alopecia, papules and brittle nails occurred in patients with ichthyosis combined with fungal infection. Various pathogenic mechanisms have been implicated, including mutations of ichthyosis\u2010related genes leading to disruption of the skin barrier via multiple pathways. Host immune disorders, including atopy and abnormal innate immunity also contribute to susceptibility. Specific fungi may escape the immune response. Extensive and recurrent fungal infections are not uncommon in patients with ichthyosis, making a cure more difficult and increasing the need for systemic antifungal therapy. Traditional and new ichthyosis treatments aiming to improve skin barrier function could help prevent fungal infection. In conclusion, the close relationship between ichthyosis and fungal infection is of vital importance in clinical practice and requires more attention from physicians. More studies are required to investigate the mechanisms and explore useful treatment strategies.<\/jats:p>","DOI":"10.1111\/ddg.14389","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T22:59:11Z","timestamp":1610751551000},"page":"341-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inherited ichthyosis and fungal infection: an update on pathogenesis and treatment strategies"],"prefix":"10.1111","volume":"19","author":[{"given":"Huilei","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Peking Union Medical College and Chinese Academy of Medical Sciences  Beijing 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