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The main challenge in reporting these morphologic features is to differentiate such benign inclusions from metastatic settlements of distinct organ tumors. As sentinel node biopsy and lymph node dissection have become standard procedure in clinical oncology and have an immense clinical impact, the correct evaluation of these nodal inclusions is indispensable to avoid undertreatment or overtreatment of patients. In addition, the genesis of these inclusions has not yet been satisfactorily clarified. Two concepts have been laid out: the theory of benign metastases and the migration arrest theory. However, neither theory has so far been able to answer the following questions: Why do we find more nodal nevi in patients with melanoma who had a sentinel node biopsy than in patients without melanoma, and why do we not find nodal nevi in deep visceral lymph nodes? We present a comprehensive review of the current knowledge on nodal inclusions, proposing a concept for the pathogenesis of nodal nevi, to answer these questions.<\/jats:p>","DOI":"10.1111\/ddg.14521","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T08:46:36Z","timestamp":1628844396000},"page":"1145-1157","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Current concepts of ectopic nodal inclusions with special emphasis on nodal nevi"],"prefix":"10.1111","volume":"19","author":[{"given":"Cornelia Sigrid Lissi","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Medical supply center for Histology Cytology and Molecular diagnostics Trier GmbH Wissenschaftspark Trier  TRIER Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan G.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of General\u2010, 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