{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:16:19Z","timestamp":1792304179743,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>CALME is the abbreviation of \u201cchildhood asymmetry labium majus enlargement\u201d and denotes a physiological, non\u2010neoplastic swelling of labium majus soft tissues. It is caused by the expansion of one or more normal vulvar tissue components and is devoid of a peripheral capsule. A few reports in the literature have raised awareness of this benign condition and stressed the need to avoid invasive procedures with possible permanent sequelae. The etiopathogenesis of CALME is still debated, although the hypothesis of a hormone\u2010driven major labia stromal hyperplasia is favored over the assumption of a benign neoplastic process. This article aims to provide a detailed review of the clinical, histological, and instrumental findings of CALME and provide a step\u2010based algorithm to approach and manage genito\u2010inguinal masses in pediatric patients.<\/jats:p>","DOI":"10.1111\/ddg.14528","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T06:33:06Z","timestamp":1624516386000},"page":"1276-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Keep CALME (childhood asymmetry labium majus enlargement) and follow up"],"prefix":"10.1111","volume":"19","author":[{"given":"Andrea","family":"Sechi","sequence":"first","affiliation":[{"name":"IRCCS University Hospital of Bologna St. Orsola\u2010Malpighi Polyclinic Dermatology Department of Experimental Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna  Bologna 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