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Thus, the aim of this work was to appraise and compare the clinical response to erbium versus CO<jats:sub>2<\/jats:sub>lasers in AS in the form of a meta\u2010analysis. The databases MEDLINE, EMBASE, Cochrane library were searched. Main clinical outcomes were investigator\u2010reported scar improvement and participant\u2010reported scar improvement. Five studies were included in this meta\u2010analysis. Scar improvement was similar for both types of laser in terms of investigator\u2010reported scar improvement (RR: 0.60 95\u00a0% CI: 0.35\u20131.02) and participant\u2010reported scar improvement (RR: 0.99 95\u00a0% CI: 0.79\u20131.25). A sensitivity analysis that excluded studies with high risk of bias found the CO<jats:sub>2<\/jats:sub>lasers to be superior to the erbium lasers (RR: 0.47 95\u00a0% CI: 0.24\u20130.93): However, the subgroup analysis showed the CO<jats:sub>2<\/jats:sub>laser not to be significantly different from either the non\u2010ablative erbium (RR: 0.65 95\u00a0% CI: 0.34\u20131.24) or the ablative erbium laser (RR: 0.60 95\u00a0% CI: 0.35\u20131.02). The CO<jats:sub>2<\/jats:sub>laser produced a slightly greater clinical response compared to the erbium lasers based on the physician\u2019s assessment. Overall, the two devices do not differ largely in terms of efficacy but may be complementary, with each resurfacing laser better suited for different clinical tasks.<\/jats:p>","DOI":"10.1111\/ddg.14546","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T22:23:03Z","timestamp":1632522183000},"page":"1559-1568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparative appraisal with meta\u2010analysis of erbium vs. CO<sub>2<\/sub>lasers for atrophic acne scars"],"prefix":"10.1111","volume":"19","author":[{"given":"Husein","family":"Husein\u2010ElAhmed","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Hospital de Baza Granada Spain"},{"name":"Translational Research Institute Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Steinhoff","sequence":"additional","affiliation":[{"name":"Translational Research Institute Hamad Medical Corporation Doha Qatar"},{"name":"Department of Dermatology and Venereology Hamad Medical Corporation Doha Qatar"},{"name":"Weill Cornell Medicine\u2010Qatar College of Medicine Doha Qatar"},{"name":"Qatar University Medical School Doha Qatar"},{"name":"Department of Dermatology Weill Cornell Medicine New York NY 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