{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:59:03Z","timestamp":1747184343856,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund<\/jats:title><jats:p>Die Dermatomyositis geh\u00f6rt zur Gruppe der seltenen, idiopathischen, inflammatorischen Myositiden. F\u00fcr die paraneoplastische Form der Dermatomyositis wurde in der Vergangenheit ein Zusammenhang mit Malignomen erkannt. Faktoren, die f\u00fcr eine Malignom\u2010Assoziation sprechen, werden bis heute untersucht.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik<\/jats:title><jats:p>Es wurden retrospektiv \u00fcber einen Zeitraum von 15 Jahren die Daten von 63 Patienten mit Dermatomyositis analysiert.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Folgende Faktoren gaben einen Hinweis f\u00fcr eine Dermatomyositis mit Malignom\u2010Assoziation: ein h\u00f6heres Patientenalter (&gt;\u00a052 Jahre [<jats:italic>P<\/jats:italic>\u00a0=\u00a00,001], &gt;\u00a065 Jahre [<jats:italic>P<\/jats:italic>\u00a0=\u00a00,002], \u2265\u00a075 Jahre [<jats:italic>P<\/jats:italic>\u00a0=\u00a00,002]), eine k\u00fcrzere Zeit zwischen Erstmanifestation und Erstdiagnose (Malignom\u2010Gruppe: 59 Tage vs. Nicht\u2010Malignom\u2010Gruppe: 137 Tage [<jats:italic>P<\/jats:italic>\u00a0=\u00a00,022]), eine Hautbeteiligung in Form von Gottron\u2010Zeichen (<jats:italic>P<\/jats:italic>\u00a0=\u00a00,045), zentrofazialen Erythemen (<jats:italic>P<\/jats:italic>\u00a0=\u00a00,036) oder typischen Erythemen an den Ober\u2010\/Unterarmen (<jats:italic>P<\/jats:italic>\u00a0=\u00a00,019), eine oropharyngeale Beteiligung (<jats:italic>P<\/jats:italic>\u00a0=\u00a00,015) und eine GPT\u2010Erh\u00f6hung (<jats:italic>P<\/jats:italic>\u00a0=\u00a00,031). Folgende Faktoren sprachen eher gegen eine Malignom\u2010Assoziation: ein j\u00fcngeres Patientenalter (\u2264\u00a052\u00a0Jahre [<jats:italic>P<\/jats:italic>\u00a0=\u00a00,001], 40\u201365 Jahre [<jats:italic>P<\/jats:italic>\u00a0=\u00a00,045]) und Juckreiz (<jats:italic>P<\/jats:italic>\u00a0=\u00a00,026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>In der Literatur finden sich heterogene Ergebnisse zu den genannten Faktoren hinsichtlich ihrer Eignung als Marker f\u00fcr eine Malignom\u2010Assoziation. Erschwert ist die Faktorenfindung aufgrund kleiner Studienpopulationen, wenigen prospektiven und kontrollierten Studien, die Einordnung von Populationen als Myositis\u2010Patienten ohne Differenzierung und eine inkonsistente Verwendung der Nomenklatur. Mit unserer Studie wollen wir einen wichtigen Beitrag zur Identifizierung von Risikofaktoren bei Dermatomyositis mit Malignom\u2010Assoziation leisten.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14566_g","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T05:45:57Z","timestamp":1637646357000},"page":"1601-1612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Charakteristika von Dermatomyositis\u2010Patienten mit und ohne Malignom\u2010Assoziation"],"prefix":"10.1111","volume":"19","author":[{"given":"Julia","family":"Lauinger","sequence":"first","affiliation":[{"name":"Universit\u00e4ts\u2010Hautklinik Eberhardt\u2010Karls\u2010Universit\u00e4t T\u00fcbingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Ghoreschi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Charit\u00e9 \u2013 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