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Periorbital squamous cell carcinoma is associated with perineural invasion in up to 14\u00a0% of cases. Specifically in this region, the proximity to cranial nerves and therefore the associated risk of progression to the central nervous system are associated with poor prognosis. The clinically concealed character of this entity often leads to a delay in diagnosis and consequently makes complete resection and reconstruction demanding. Careful clinical evaluation often hints at perineural invasion before obtaining histology.<\/jats:p><jats:p>Aside from presenting five challenging cases, this work analyzes risk factors, clinical as well as histological features, and treatment options for periorbital squamous cell carcinoma with perineural invasion.<\/jats:p>","DOI":"10.1111\/ddg.14582","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T05:45:57Z","timestamp":1637646357000},"page":"1571-1580","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hide\u2010and\u2010seek: Neurotropic squamous cell carcinoma of the periorbital region \u2013 a series of five cases and review of the literature"],"prefix":"10.1111","volume":"19","author":[{"given":"Evi M.","family":"Morandi","sequence":"first","affiliation":[{"name":"Department of Plastic Reconstructive and Aesthetic Surgery Medical University of Innsbruck  Innsbruck 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