{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T04:38:37Z","timestamp":1692592717410},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Pemphigus ist mit physischen und psychischen Erkrankungen assoziiert. Diese Studie soll derartige Zusammenh\u00e4nge bei Patienten mit Pemphigus n\u00e4her untersuchen sowie die Komorbidit\u00e4t nach Geschlecht, Alter, dem <jats:italic>Pemphigus Disease Area Index<\/jats:italic>, der Diagnoseverz\u00f6gerung und der Beteiligung von Haut\/Schleimhaut analysieren.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methoden<\/jats:title><jats:p>Jedem Pemphigus\u2010Patienten wurden acht Kontrollen mit \u00e4hnlichem Alter, Geschlecht und Wohnsitz zugeordnet. Die Wahrscheinlichkeit f\u00fcr Begleiterkrankungen bei Patienten und Kontrollpersonen wurde anhand univariater konditionaler Regressionsmodelle bestimmt. Begleiterkrankungen, die in den univariaten Modellen mit <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00,05 mit der Diagnose Pemphigus assoziiert waren, wurden dann in einem Vorw\u00e4rtsverfahren in ein multivariates konditionales Regressionsmodell eingef\u00fcgt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Die Studie umfasste 163\u00a0Patienten mit Pemphigus. Die haupts\u00e4chlichen Erkrankungen zum Diagnosezeitpunkt waren kardiovaskul\u00e4re Erkrankungen, Hyperlipid\u00e4mie, Autoimmunerkrankungen der Schilddr\u00fcse, autoimmune\/entz\u00fcndliche Dermatosen und Krebs. In der multivariaten konditionalen Regressionsanalyse waren Krebs und autoimmune\/entz\u00fcndliche Dermatosen unabh\u00e4ngig mit Pemphigus assoziiert. In Sensitivit\u00e4tsanalysen, in denen vier Patienten mit paraneoplastischem Pemphigus ausgeschlossen wurden, waren diese Assoziationen ebenfalls signifikant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Krebs und autoimmune\/entz\u00fcndliche Dermatosen sind m\u00f6glicherweise ausl\u00f6sende Faktoren f\u00fcr Pemphigus dar und sollten als fr\u00fche Warnsignale f\u00fcr diese Erkrankung angesehen werden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14595_g","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T05:45:57Z","timestamp":1637646357000},"page":"1613-1620","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Komorbidit\u00e4t bei Pemphigus: eine Fall\u2010Kontroll\u2010Studie"],"prefix":"10.1111","volume":"19","author":[{"given":"Federico","family":"Bardazzi","sequence":"first","affiliation":[{"name":"Department of Experimental 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