{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:41:51Z","timestamp":1693140111444},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Bei Patienten mit aktivem Pemphigus liegt ein erhebliches Ausma\u00df an psychischer Morbidit\u00e4t vor. Da Pemphigus eine chronische Krankheit ist, kann psychische Morbidit\u00e4t auch bei Pemphigus\u2010Patienten in Remission auftreten. Die Ziele dieser Studie waren die Beurteilung der psychischen Morbidit\u00e4t bei Pemphigus\u2010Patienten in klinischer Remission und des Zusammenhangs mit klinisch\u2010demographischen Parametern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methodik<\/jats:title><jats:p>Pemphigus\u2010Patienten in klinischer Remission wurden konsekutiv in die Studie eingeschlossen und um Beantwortung des <jats:italic>Patient Health Questionnaire<\/jats:italic> (PHQ\u20109), des <jats:italic>Generalized Anxiety Disorder<\/jats:italic>\u2010Bogens GAD\u20107 und des Moduls zu Panikst\u00f6rungen des PHQ in der englischen oder der Hindi\u2010Version gebeten.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Von 107 rekrutierten Patienten hatten 41 (38,3 %, 95 %\u2010KI: 29,1\u201348,2 %) entweder eine Depression (33 [30,8 %, 95 %\u2010KI: 22,2\u201340,5 %]) oder eine Angstst\u00f6rung (38 [35,5 %, 95 %\u2010KI: 26,5\u201345,4 %] gem\u00e4\u00df dem Cut\u2010off\u2010Wert des PHQ\u20109 beziehungsweise des GAD\u20107. Die Zahl der Patienten mit leichter, m\u00e4\u00dfiger, mittelschwerer\/schwerer Depression betrug 26 (24,3 %, 95 %\u2010KI: 17,2\u201333,2 %), 7 (6,5 %, 95 %\u2010KI: 0,3\u201312,9 %) beziehungsweise 0. Die Zahl der Patienten mit leichter, m\u00e4\u00dfiger und schwerer Angstst\u00f6rung lag bei 29 (27,1 %, 95 %\u2010KI: 19,6\u201336,2 %), 9 (8,4 %, 95 %\u2010KI: 4,5\u201315,2 %) beziehungsweise 0. Patienten mit Angstst\u00f6rung oder Depression in der Vergangenheit wiesen zum Zeitpunkt der Beurteilung deutlich h\u00f6here klinische Krankheitsaktivit\u00e4t, mehr Tage in station\u00e4rer dermatologischer Behandlung sowie eine signifikant k\u00fcrzere klinische Remission auf als Patienten ohne diese Symptome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Eine signifikante Belastung durch leichtes\/m\u00e4\u00dfiges Depressions\u2010 oder Angstsyndrom war mit der vorangegangenen Krankheitsschwere und k\u00fcrzerer Dauer der klinischen Remission assoziiert.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Significant psychological morbidity exists in patients with active pemphigus. Pemphigus being a chronic disease, psychological morbidity may exist in pemphigus patients in remission as well. The objectives of the study were to assess the psychological morbidity in pemphigus patients in clinical remission and to correlate it with clinico\u2010demographic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Pemphigus patients in clinical remission were consecutively included and were asked to respond to the Hindi\/English version of Patient Health Questionnaire (PHQ\u20109), Generalized Anxiety Disorder (GAD\u20107) and panic disorder module of PHQ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 107 patients recruited, 41 (38.3 %, 95 % CI: 29.1\u201348.2 %) patients were found to have either depression (33 [30.8 %, 95 % CI: 22.2\u201340.5 %]) or anxiety (38 [35.5 %, 95 % CI: 26.5\u201345.4 %] syndrome based on cut\u2010offs of PHQ\u20109 score and GAD\u20107 score, respectively. Number of patients with mild, moderate and moderately severe\/severe depression syndrome were 26 (24.3 %, 95 % CI: 17.2\u201333.2 %), 7 (6.5 %, 95 % CI: 0.3\u201312.9 %) and 0 respectively and patients with mild, moderate, severe anxiety syndrome were 29 (27.1 %, 95 % CI: 19.6\u201336.2 %), 9 (8.4 %, 95 % CI: 4.5\u201315.2 %) and 0 respectively. Patients with anxiety or depression syndrome had significantly higher clinical disease activity in the past, number of days spent in dermatology inpatient and significantly shorter clinical remission at the time of assessment as compared to those without these symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant burden of mild\/moderate depression or anxiety syndrome associated with past severity of disease and shorter duration of clinical remission was found.<\/jats:p><\/jats:sec><\/jats:sec>","DOI":"10.1111\/ddg.14605_g","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T10:48:23Z","timestamp":1642502903000},"page":"26-34","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychische Morbidit\u00e4t bei Pemphigus\u2010Patienten in klinischer Remission und deren Zusammenhang mit klinisch\u2010demographischen 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