{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:53:02Z","timestamp":1788893582704,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Molluscum contagiosum (MC) is a common viral infection. Hypersensitivity reactions reminiscent of Gianotti\u2010Crosti syndrome, termed Gianotti\u2010Crosti syndrome\u2010like reaction (GCLR), have been reported in a subset of patients. We report a series of patients with GCLR, better delineating its clinical presentation and course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Retrospective chart review of all children presenting with GCLR at our Pediatric Skin Center between 2015 and 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>26 children (14 boys) with a median age of 6.5 (3\u201311.3) years were included. GCLR involved the extensor surfaces of the extremities in all patients. More widespread eruptions also affected the trunk and face in 7 (27\u00a0%) and 6 (23\u00a0%) children respectively. Involvement of the skin overlying the Achilles tendons was a new finding in 4 (15\u00a0%) children. Itch was the predominant symptom in 20 (77\u00a0%) patients. The rash responded to topical and\/or systemic corticosteroids and resolved within four weeks. GCLR was followed by clearance of MC in all patients within 9 (4\u201324) weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GCLR is a characteristic acute, wide\u2010spread, pruritic papular eruption, which often leads to emergency consultations and anxiety in affected patients. GCLR responds well to corticosteroid treatment, has a benign course, and heralds the healing of MC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14608","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T06:44:45Z","timestamp":1636613085000},"page":"1746-1751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gianotti\u2010Crosti syndrome\u2010like reaction to molluscum contagiosum\u2013Clinical characteristics and response to treatment"],"prefix":"10.1111","volume":"19","author":[{"given":"Christina","family":"B\u00fcrgler","sequence":"first","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children\u2019s Hospital Zurich  Zurich Switzerland"},{"name":"Department of Dermatology Inselspital Bern University Hospital University of Bern  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Weibel","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children\u2019s Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Schwieger\u2010Briel","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children\u2019s Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kn\u00f6pfel","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children\u2019s Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Luchsinger","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children\u2019s Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Theiler","sequence":"additional","affiliation":[{"name":"Pediatric Skin Center Dermatology Department University Children\u2019s Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327888"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2414"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1996.tb01254.x"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"265","article-title":"Papular acrodermatitis of childhood related to poxvirus and parvovirus B19 infection","volume":"61","author":"Carrascosa 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etiologies?","volume":"8","author":"Chun A","year":"2016","journal-title":"Infect Dis Rep"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.14608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ddg.14608","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.14608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T17:28:46Z","timestamp":1692811726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.14608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,10]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/ddg.14608"],"URL":"https:\/\/doi.org\/10.1111\/ddg.14608","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,10]]},"assertion":[{"value":"2020-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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