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A rapid diagnosis and appropriate management of these side effects are crucial to prevent impairment of the patients\u2019 quality of life and interruptions of essential cancer treatments. Immune checkpoint and EGFR inhibitors are frequently used targeted therapies for various malignancies and are associated with a distinct spectrum of cutaneous adverse events. Exanthematous drug eruptions represent a particular diagnostic challenge in these patients. Immune checkpoint inhibitors can elicit a plethora of immune\u2010related exanthemas, most commonly maculopapular, lichenoid, and psoriasiform eruptions. Additionally, autoimmune bullous dermatoses and exanthemas associated with connective tissue diseases may arise. In cases of severe, atypical or therapy\u2010resistant presentations an extensive dermatological investigation including a skin biopsy is recommended. Topical and systemic steroids are the mainstay of treatment. Papulopustular eruptions represent the major cutaneous adverse effect of EGFR inhibitor therapy, occurring in up to 90\u00a0% of patients within the first two weeks of therapy, depending on the agent. Besides topical antibiotics and steroids, oral tetracyclines are the first choice in systemic treatment and can also be used as prophylaxis.<\/jats:p>","DOI":"10.1111\/ddg.14641","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T05:45:57Z","timestamp":1637646357000},"page":"1621-1643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Drug eruptions with novel targeted therapies \u2013 immune checkpoint and EGFR inhibitors"],"prefix":"10.1111","volume":"19","author":[{"given":"Isabella","family":"Pospischil","sequence":"first","affiliation":[{"name":"Department of Dermatology Kepler University Hospital Johannes Kepler University  Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Hoetzenecker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kepler University Hospital Johannes Kepler University  Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/ddg.13362_g","article-title":"Sp\u00e4ttypreaktionen durch oral und parenteral applizierte Arzneimittel","volume":"15","author":"Brandt O","year":"2017","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_16_3_1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/ddg.130_12747","article-title":"Schwere arzneimittelinduzierte Hautreaktionen: Klinik, Diagnostik, \u00c4tiologie und Therapie","volume":"13","author":"Paulmann M","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00049"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy162"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0336-3"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17245"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13876"},{"key":"e_1_2_16_9_1","volume-title":"Common terminology criteria for adverse events (CTCAE) version 5.0. 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