{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:41:01Z","timestamp":1765546861101},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Total skin electron beam therapy (TSEBT) combined with systemic therapy or maintenance treatment is a reasonable approach to enhance the remission rate and duration in mycosis fungoides (MF) and S\u00e9zary syndrome (SS). This study assesses the efficacy of oral bexarotene therapy after low\u2010dose TSEBT for patients with MF and SS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective observational study, we recruited MF\/SS patients for treatment with low\u2010dose total skin electron beam therapy (TSEBT) with or without bexarotene therapy to describe outcomes and toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six subjects with MF or SS underwent TSEBT between 2016 and 2021 at our institute. Following TSEBT, 27 patients (59\u00a0%) received oral bexarotene treatment. The median follow\u2010up was 13 months. The overall response rate (ORR) for the cohort was 85\u00a0%. The response rate was significantly higher with combined modality (CM) than TSEBT alone (96\u00a0% vs. 68\u00a0%, p = 0.03). Median progression\u2010free survival (PFS) for the CM was 17 months versus five months following TSEBT alone (p = 0.001). One patient (4\u00a0%) in the retinoid group discontinued the bexarotene therapy because of adverse events. The administration of bexarotene therapy did not increase radiation\u2010related toxicities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Response rate and progression\u2010free survival might be improved with TSEBT in combination with oral bexarotene compared to TSEBT alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14657","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T09:13:18Z","timestamp":1641373998000},"page":"279-285","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Low\u2010dose total skin electron beam therapy plus oral bexarotene maintenance therapy for cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"20","author":[{"given":"Khaled","family":"Elsayad","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University Hospital of Muenster  Munster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rolf","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital of Muenster  Munster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cord","family":"Sunderk\u00f6tter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Weishaupt","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Muenster  Munster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa Christina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital of Muenster  Munster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Nawar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital of Muenster  Munster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Stranzenbach","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Stadler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Johannes Wesling Medical Centre University of Bochum  Minden German"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Muenster  Munster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose K. 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