{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T11:08:59Z","timestamp":1722424139187},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin\u00a0D has emerged as a promising treatment for congenital ichthyosis for which no comparative studies exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>In this randomized, double\u2010blinded study, patients with congenital ichthyosis received either Vitamin\u00a0D 2000 IU\/day (group\u00a0A) or acitretin 0.5\u00a0mg\/kg\/day (group\u00a0B) for 24\u00a0weeks. The primary outcome was improvement in the <jats:italic>Visual Index for Ichthyosis Severity<\/jats:italic> (VIIS) and <jats:italic>Ichthyosis Area Severity Index<\/jats:italic> (IASI). Secondary outcomes included <jats:italic>Ichthyosis Quality of Life Index\u201032<\/jats:italic> (IQoL\u201032), mRNA expression of ROR\u03b3t and IL\u201017 and adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients completed the study. Group\u00a0A (n = 11) showed a significant decrease in VIIS (<jats:italic>p<\/jats:italic> = 0.023) and IASI (<jats:italic>p<\/jats:italic> = 0.026) at 12 but not 24 weeks. Group\u00a0B (n = 13) showed a significant decrease in IASI at 24 weeks only (<jats:italic>p<\/jats:italic> = 0.016). The IQoL\u201032 improved over 24 weeks in both groups. A significant decrease in the mRNA expression of ROR\u03b3t (<jats:italic>p<\/jats:italic> = 0.048) and IL\u201017 (<jats:italic>p<\/jats:italic> = 0.023) was seen only in group\u00a0A. There was no significant difference between the two treatment arms in terms of VIIS, IASI and IQol\u201032 at 12 and 24 weeks. No serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin\u00a0D maybe an alternative to acitretin in the treatment of congenital ichthyosis where it reduces the expression of ROR\u03b3t and IL\u201017.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14666","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T12:14:58Z","timestamp":1645877698000},"page":"297-304","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral vitamin\u00a0D versus acitretin in congenital non\u2010syndromic ichthyosis: double blinded, randomized controlled trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Shirin","family":"Bakshi","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology, and Leprology Postgraduate Institute of Medical Education and Research  Sector 12 Chandigarh 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