{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:35:44Z","timestamp":1783488944490,"version":"3.55.0"},"reference-count":201,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Zusammenfassung<\/jats:title><jats:p>Die Alopecia areata (AA) ist eine chronische immunvermittelte Erkrankung, die durch akuten oder chronischen, nicht vernarbenden Haarausfall gekennzeichnet ist. Die klinischen Erscheinungsformen sind sehr unterschiedlich und reichen von kleinen umschriebenen haarlosen Stellen bis hin zum vollst\u00e4ndigen Verlust der Kopf\u2010 und K\u00f6rperbehaarung. Diese \u00dcbersicht soll aktuelles Wissen zu Pathophysiologie und beteiligten Signalwegen vermitteln sowie diagnostische und therapeutische Empfehlungen geben. Aktuell verf\u00fcgbare Therapieans\u00e4tze bei AA, einschlie\u00dflich topischer, systemischer und injizierbarer Interventionen, zeigen unterschiedlich gutes Ansprechen mit h\u00e4ufigen Rezidiven, was den dringenden Bedarf an effektiven zielgerichteten Therapien widerspiegelt. Neue therapeutische Ans\u00e4tze und Konzepte, einschlie\u00dflich Januskinase\u2010Inhibitoren, werden mit gro\u00dfer Spannung erwartet. Diese \u00dcbersicht diskutiert traditionelle und neue Therapieans\u00e4tze f\u00fcr das Management der AA. Diese Erkrankung f\u00fchrt h\u00e4ufig zu einer starken psychosozialen Belastung f\u00fcr die Betroffenen, kann zu Depressionen f\u00fchren, Angstzust\u00e4nde ausl\u00f6sen und die Lebensqualit\u00e4t beeintr\u00e4chtigen. Daher sollten psychosoziale Aspekte der Krankheit mit ber\u00fccksichtigt, beim Patienten angesprochen und die Notwendigkeit einer psychologischen Unterst\u00fctzung erwogen werden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary<\/jats:title><jats:p>Alopecia areata (AA) is a chronic, immune\u2010mediated disease characterized by acute or chronic non\u2010scarring hair loss, with a heterogeneity in clinical manifestations ranging from patchy hair loss to complete scalp and body hair loss. An overview of the up\u2010to\u2010date pathophysiology and the underlying signaling pathways involved in AA together with diagnostic and therapeutic recommendations will be provided. Current treatments, including topical, systemic and injectable interventions show varying response and frequent relapses reflecting the unmet clinical need. Thus, the new emerging concepts and therapeutic approaches, including Janus kinase inhibitors are eagerly awaited. Traditional and emerging therapies of AA will be discussed, in order to provide physicians with guidance for AA management. Since the latter is so challenging and often tends to take a chronic course, it can have an enormous psychosocial burden on patients, compromising their quality of life and often causing depression and anxiety. Therefore, the psychosocial aspects of the disease need to be evaluated and addressed, in order to implement appropriate psychological support when needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14689_g","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T10:48:23Z","timestamp":1642502903000},"page":"59-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alopecia areata \u2013 Aktuelles Verst\u00e4ndnis und Management"],"prefix":"10.1111","volume":"20","author":[{"given":"Dimitra Aikaterini","family":"Lintzeri","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie Venerologie und Allergologie Clinical Research Center for Hair and Skin Science Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andria","family":"Constantinou","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr 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