{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T11:50:45Z","timestamp":1742385045280},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,4]]},"abstract":"Summary<\/jats:title>Background and objectives<\/jats:title>Pemphigus diseases are potentially life\u2010threatening and rare autoimmune bullous disorders characterized by blisters and erosions of the skin and mucous membranes. These disorders can be largely divided into two major subtypes: pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The objective of this study was to evaluate the autoantibody profile and response to therapy of PV and PF patients by analyzing the clinicopathological data from a registry for bullous autoimmune dermatoses.<\/jats:p><\/jats:sec>Patients and methods<\/jats:title>In a retrospective study, data from 69 patients with PV and PF were included in the analysis. The Autoimmune Bullous Skin Intensity Score (ABSIS) was used to assess the clinical course, remissions, relapses and severity of the disease at first manifestation and throughout the observation period. ELISA was performed to assess levels of anti\u2010desmoglein (Dsg)\u20101 and anti\u2010Dsg3 IgG serum autoantibodies.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean remission time in PV and PF patients was 63 weeks. PV patients with mucosal involvement showed a more favorable healing process. In PV patients with a moderate\/high anti\u2010Dsg1 IgG serum level at baseline, anti\u2010Dsg3 IgG levels decreased during the observation period.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study provides additional insights into the clinical course of patients with PV and PF, revealing that a mucosal phenotype is associated with a higher tendency towards remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14695","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T13:48:58Z","timestamp":1650548938000},"page":"461-467","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Disease progression and response to therapy in pemphigus based on a registry"],"prefix":"10.1111","volume":"20","author":[{"given":"Josquin","family":"Pieper","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pollmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Eming","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Greene","sequence":"additional","affiliation":[{"name":"Institute of Medical Bioinformatics and Biostatistics Philipps\u2010University Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maik","family":"Hahmann","sequence":"additional","affiliation":[{"name":"Coordination Center for Clinical Studies (KKS) Philipps\u2010University Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1854"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90360-B"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8662-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.26"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S75908"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-017-0008-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/321950"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20199011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14405"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2007.00593.x"},{"key":"e_1_2_8_12_1","volume-title":"R: A Language and Environment for Statistical Computing. 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