{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:36:44Z","timestamp":1692679004247},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Pemphigus geh\u00f6rt zu den seltenen, aber potentiell lebensbedrohlichen Autoimmunerkrankungen. Typisch sind Blasen und Erosionen der Haut und der Schleimh\u00e4ute. Grunds\u00e4tzlich unterscheiden wir zwei Subtypen: Pemphigus vulgaris (PV) und Pemphigus foliaceus (PF). In dieser Studie wurden die klinisch\u2010pathologischen Daten aus einem Register f\u00fcr bull\u00f6se Autoimmundermatosen analysiert mit dem Ziel, das Autoantik\u00f6rperprofil und das Therapieansprechen bei Patienten mit PV und PF genauer zu charakterisieren.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methoden<\/jats:title><jats:p>In einer retrospektiven Studie wurden die Daten von 69 Patienten mit PV und PF analysiert. Zur Beurteilung des klinischen Verlaufs, der Remissionen und Rezidive sowie des Schweregrads der Krankheit bei Erstmanifestation und w\u00e4hrend des gesamten Beobachtungszeitraums diente der ABSIS (<jats:italic>Autoimmune Bullous Skin Intensity Score<\/jats:italic>) (ABSIS). Mittels ELISA wurden die Spiegel von Anti\u2010Desmoglein (Dsg)\u20101\u2010 und Anti\u2010Dsg\u2010 IgG\u2010Autoantik\u00f6rpern im Serum bestimmt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Die mittlere Remissionszeit bei Patienten mit PV und PF betrug 63\u00a0Wochen. PV\u2010Patienten mit Schleimhautbeteiligung zeigten eine schnellere Heilung. Bei PV\u2010Patienten mit moderat oder stark erh\u00f6hten Anti\u2010Dsg1\u2010IgG\u2010Autoantik\u00f6rpern im Serum zu Beginn erfolgte im Lauf des Beobachtungszeitraums ein Absinken der Anti\u2010Dsg3\u2010IgG\u2010Spiegel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Unsere Studie liefert neue Erkenntnisse zum Krankheitsverlauf bei Patienten mit PV und PF und offenbart, dass ein Ph\u00e4notyp mit Schleimhautbeteiligung eine st\u00e4rkere Neigung zur Remission aufweist.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14695_g","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T13:48:58Z","timestamp":1650548938000},"page":"461-468","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Register\u2010Studie zu Krankheitsentwicklung und Therapieansprechen bei Pemphigus"],"prefix":"10.1111","volume":"20","author":[{"given":"Josquin","family":"Pieper","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie Universit\u00e4tsklinikum Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Pollmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie Universit\u00e4tsklinikum Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Eming","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie Universit\u00e4tsklinikum Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Greene","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Bioinformatik und Biostatistik Philipps\u2010 Universit\u00e4t Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maik","family":"Hahmann","sequence":"additional","affiliation":[{"name":"Koordinierungszentrum f\u00fcr Klinische Studien (KKS) Philipps\u2010 Universit\u00e4t Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie Universit\u00e4tsklinikum Marburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1854"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90360-B"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8662-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.26"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S75908"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41702-017-0008-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/321950"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20199011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14405"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9868.2007.00593.x"},{"key":"e_1_2_7_12_1","volume-title":"R: A Language and Environment for Statistical Computing. 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