{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:44:56Z","timestamp":1792446296481,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>This study aimed to investigate the association of vitiligo with metabolic syndrome (MetS) and its relevant components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We searched PubMed, Web of Science, Cochrane Library and Embase databases from inception to March 30, 2021, for relevant studies. Cross\u2010sectional and case\u2010control studies that reported either the prevalence or odds ratio [OR] of MetS or its components in vitiligo patients were included. Data were pooled using either random\u2010effects model or fixed\u2010effects model according to the heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty studies with a total of 28,325 vitiligo patients were included. Significant associations were found between vitiligo and diabetes mellitus (pooled OR, 3.30; 95\u00a0% confidence interval [CI], 2.10\u20135.17) and between vitiligo and obesity (pooled OR, 2.08; 95\u00a0% CI, 1.40\u20133.11). The overall prevalence of hypertension in the patients with vitiligo was 19.0\u00a0% (95\u00a0% CI, 2.0\u00a0%\u201336.0\u00a0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest the association of vitiligo with diabetes mellitus, obesity, and hypertension. It is recommended for dermatologists to take these associations into account so as to identify potential comorbidities promptly in vitiligo patients. Additionally, vitiligo patients are advised to monitor the indexes including BMI, blood glucose, and blood pressure levels and the consultation with specialists is necessary upon abnormal changes of these indexes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14717","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T11:15:19Z","timestamp":1651490119000},"page":"629-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association between vitiligo and relevant components of metabolic syndrome: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Pan","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital Fourth Military Medical University  Xi\u2019an Shaanxi China"},{"name":"Department of Epidemiology School of Public Health Fourth Military Medical University  Xi\u2019an Shaanxi 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