{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:41:18Z","timestamp":1774273278323,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The porphyrias are clinically variable and genetically heterogeneous, predominantly hereditary metabolic diseases, which are caused by a dysfunction of specific enzymes in heme biosynthesis. Here, we provide an overview of the etiopathogenesis, clinic, differential diagnosis, laboratory diagnostics and therapy of these complex metabolic disorders and cover in detail the most common form of porphyria worldwide (porphyria cutanea tarda), the most frequent childhood porphyria (erythropoietic protoporphyria), and the most common neurocutaneous porphyria (variegate porphyria).<\/jats:p>","DOI":"10.1111\/ddg.14743","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T11:43:17Z","timestamp":1647690197000},"page":"316-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Porphyrias"],"prefix":"10.1111","volume":"20","author":[{"given":"Wiebke","family":"Muschalek","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Hospital G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias A.","family":"Hermasch","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Hospital G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Poblete\u2010 Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Dienst Dermatologie Ziekenhuis Oost\u2010Limburg (ZOL) und Praktijk Huidziekten Genk  Genk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Hospital G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,19]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.05.009"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000257260"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3748-0"},{"key":"e_1_2_17_5_1","first-page":"230","article-title":"The porphyrias: clinical presentation, diagnosis and treatment","volume":"16","author":"Poblete\u2010Gutierrez P","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(04)93770-2"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2004.03.013"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.08.010"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3745-3"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3741-7"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2019.01.004"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.07.002"},{"key":"e_1_2_17_13_1","first-page":"1","article-title":"Studien \u00fcber Porphyrie","author":"Waldenstr\u00f6m J","year":"1937","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_2_17_14_1","first-page":"63","article-title":"The cutaneous porphyrias","volume":"9","author":"Elder GH","year":"1990","journal-title":"Semin Dermatol"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007142"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm2035140"},{"key":"e_1_2_17_17_1","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/ddg.13590","article-title":"Blistering of the hands following a manicure at a nail salon","volume":"16","author":"Langer E","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-018-4344-x"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1112755"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1988.tb01216.x"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(83)90369-4"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009745"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00160-X"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00438257"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)92427-8"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02283.x"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.80"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/498620"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng809"},{"key":"e_1_2_17_30_1","first-page":"292","article-title":"Modulation of the phenotype in dominant erythropoietic protoporphyria by a low expression of the normal ferrochelatase allele","volume":"58","author":"Gouya L","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0557-1"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.06920.x"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3733-7"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-006-1155-2"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411481"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0210-5705(05)71529-6"},{"key":"e_1_2_17_37_1","first-page":"117","article-title":"Further South African cases of porphyrinuria","volume":"2","author":"Barnes HD","year":"1951","journal-title":"S Afr J Clin Sci"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(80)90173-1"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10606.x"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-95"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00148.x"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029854"},{"key":"e_1_2_17_43_1","first-page":"381","article-title":"Two new mutations in the PPOX gene in a patient with variegate porphyria","volume":"18","author":"Collantes\u2010Rodriguez C","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640290053010"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913147"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04547-3"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12411"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12391"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.14743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ddg.14743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.14743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T10:13:30Z","timestamp":1693131210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.14743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/ddg.14743"],"URL":"https:\/\/doi.org\/10.1111\/ddg.14743","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"2021-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}