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The strongest evidence for psoriasis therapy during pregnancy exists for topical corticosteroids. Medically controlled use of UVB\u2010therapy is also considered safe. The best evidence regarding systemic therapy during pregnancy and lactation is available for the group of TNF\u2010alpha inhibitors, which is also reflected in the respective medical product information. This is especially important in cases of psoriatic arthritis. Among traditional systemic therapeutics, the largest clinical experience exists for ciclosporin, which, if medically necessary, may be continued during gestation. However, TNF\u2010alpha inhibitors, especially the pegylated form, should be preferred in case of pregnancy. Furthermore, an elective pregnancy termination is not necessary due to systemic therapy of psoriasis with many further substances during the first pregnancy weeks. The current work provides a comprehensive review of the scientific literature on treatment of psoriasis during pregnancy and lactation. Based on the available scientific information, severity of psoriasis and patient\u2019s comorbidities, the best possible therapeutic approach can be found in consensus with the patient.<\/jats:p>","DOI":"10.1111\/ddg.14789","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T04:54:40Z","timestamp":1652763280000},"page":"653-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Therapy of psoriasis during pregnancy and breast\u2010feeding"],"prefix":"10.1111","volume":"20","author":[{"given":"Galina","family":"Balakirski","sequence":"first","affiliation":[{"name":"Center for Dermatology Allergology and Dermatosurgery HELIOS University Hospital Wuppertal Witten\/Herdecke University  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Gerdes","sequence":"additional","affiliation":[{"name":"Psoriasis Center Department of Dermatology Venereology and Allergology University Hospital Schleswig\u2010 Holstein \u2013 Campus Kiel  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Beissert","sequence":"additional","affiliation":[{"name":"Department and Clinic for Dermatology University Hospital Carl Gustav Carus  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Ochsendorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology University Hospital Frankfurt am Main  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"von Kiedrowski","sequence":"additional","affiliation":[{"name":"Specialized Dermatological Practice  Selters\/Westerwald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wilsmann\u2010Theis","sequence":"additional","affiliation":[{"name":"Department and Clinic for Dermatology and 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