{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:40:30Z","timestamp":1692679230108},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Ziele<\/jats:title><jats:p>Lichen planus (LP) ist eine chronisch entz\u00fcndliche Hauterkrankung, die eine gro\u00dfe Belastung f\u00fcr die betroffenen Patienten darstellt. Es liegen jedoch nur wenige Daten zu dieser Erkrankung vor. Ziel dieser Studie ist es, das Wissen \u00fcber die Epidemiologie und die Behandlungsmuster des LP anhand von Abrechnungsdaten deutscher Krankenkassen zu erweitern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methoden<\/jats:title><jats:p>Diese retrospektive Beobachtungsstudie nutzte die InGef\u2010Forschungsdatenbank. Es wurden pr\u00e4valente und inzidente LP\u2010Patienten aus den Jahren 2015 und 2018 identifiziert. F\u00fcr demografische Charakteristika, Behandlungsmuster und Komorbidit\u00e4t wurden deskriptive Statistiken berechnet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Die Pr\u00e4valenz des LP lag bei 95,9 und die Inzidenz bei 20,1 pro 100 000 Personen im Jahr 2018, was 79\u00a0605 pr\u00e4valenten LP\u2010F\u00e4llen in Deutschland entspricht. Die erste LP\u2010Diagnose wurde in der Regel von einem Dermatologen oder Hausarzt gestellt. Drei Viertel der inzidenten und die H\u00e4lfte der pr\u00e4valenten Patienten erhielten eine topische Therapie, meist ohne zus\u00e4tzliche systemische Therapie. Die Komorbidit\u00e4t des LP stand im Einklang mit bereits bekannten Assoziationen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Die verf\u00fcgbaren Therapieoptionen sind nach wie vor begrenzt, was den ungedeckten Bedarf an sicheren und wirksamen systemischen Behandlungsmodalit\u00e4ten unterstreicht. Der LP ist h\u00e4ufig mit klinisch relevanter systemischer Komorbidit\u00e4t verbunden. Zusammengenommen k\u00f6nnten diese Beobachtungen zu einem verbesserten Verst\u00e4ndnis der Krankheitslast f\u00fchren und das diagnostische Bewusstsein f\u00fcr diese Erkrankung unter Klinikern sch\u00e4rfen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14808_g","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T05:45:04Z","timestamp":1660628704000},"page":"1101-1111","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lichen planus in Deutschland \u2013 Epidemiologie, Behandlung und Komorbidit\u00e4t. Eine retrospektive Krankenkassendatenanalyse"],"prefix":"10.1111","volume":"20","author":[{"given":"Eva","family":"Schruf","sequence":"first","affiliation":[{"name":"Novartis Pharma GmbH  N\u00fcrnberg Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona HC","family":"Biermann","sequence":"additional","affiliation":[{"name":"Novartis Pharma GmbH  N\u00fcrnberg Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Jacob","sequence":"additional","affiliation":[{"name":"InGef\u2010Institut f\u00fcr angewandte Gesundheitsforschung Berlin GmbH  Berlin Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"H\u00e4ckl","sequence":"additional","affiliation":[{"name":"WIG2 GmbH  Leipzig Deutschland"},{"name":"Universit\u00e4t Leipzig  Leipzig 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