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Across published literature, triggers for FDE are widely varied. The most frequently implicated drugs include analgesics (nonsteroidal anti\u2010inflammatory drugs [NSAIDs] and paracetamol) and antibiotics. Co\u2010trimoxazole is perhaps the most well described single agent. Since the start of the century there have been over 200 drugs named in case reports on FDE. Newer, novel agents of note include cyclooxygenase\u20102 specific inhibitors, fluconazole, and phosphodiesterase\u00a05 inhibitors. Other implicated drugs include vaccines, such as various SARS\u2010CoV\u20102 vaccines.<\/jats:p><jats:p>Drugs incriminated in FDE vary based on the geographical region studied and prescribing patterns at a given time. Newer drugs continue to enter the market and are playing an increasing role in the field of FDE. Awareness of rarer culprits and emerging novel agents can help identify a trigger, allowing for prompt withdrawal of the causative agent, preventing recurrence.<\/jats:p>","DOI":"10.1111\/ddg.14870","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T23:35:25Z","timestamp":1665358525000},"page":"1289-1302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fixed drug eruptions \u2013 the common and novel culprits since 2000"],"prefix":"10.1111","volume":"20","author":[{"given":"Jessica","family":"McClatchy","sequence":"first","affiliation":[{"name":"Dermatology Department The Royal Melbourne Hospital Melbourne Australia"},{"name":"Faculty of Medicine Dentistry and Health Sciences The University of Melbourne Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Yap","sequence":"additional","affiliation":[{"name":"Dermatology Department 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