{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:09:23Z","timestamp":1721387363061},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund und Zielsetzungen<\/jats:title><jats:p>Die Behandlungsoptionen f\u00fcr mittelschwere bis schwere Hidradenitis suppurativa (HS) umfassen Antibiotika, Biologika und verschiedene chirurgische Verfahren. Diese Ans\u00e4tze unterscheiden sich stark bez\u00fcglich des Behandlungsprozesses, der Erfolgsraten und der unerw\u00fcnschten Ereignisse. Informationen zu den Pr\u00e4ferenzen der Patienten in Bezug auf HS\u2010Therapien gibt es aktuell nur wenige. Unser Ziel war es, Patientenpr\u00e4ferenzen f\u00fcr die medikament\u00f6se und chirurgische Behandlung der HS durch Conjoint\u2010Analyse zu untersuchen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methoden<\/jats:title><jats:p>In dieser Querschnittsstudie wurden durch computergest\u00fctzte \u201eDiscrete\u2010Choice\u201c Experimente die Pr\u00e4ferenzen der Patienten f\u00fcr HS\u2010Therapien quantifiziert, und zwar aufgeschl\u00fcsselt nach Behandlungsmodalit\u00e4t (Tabletten, subkutane Injektionen, chirurgische Eingriffe mit sekund\u00e4rer Heilungsabsicht oder prim\u00e4rer Verschluss), Wahrscheinlichkeit eines anhaltenden Therapieerfolgs, Wahrscheinlichkeit leichter oder schwerer unerw\u00fcnschter Ereignisse und Dauer der Behandlung oder Wundheilung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Gemittelt \u00fcber die Kohorte (n\u00a0=\u00a0216 Patienten mit HS) wurde der anhaltende Therapieerfolg als am wichtigsten angesehen (<jats:italic>Relative Importance Score<\/jats:italic> [RIS]: 36,2), gefolgt von der Behandlungsmodalit\u00e4t (RIS: 24,0) und der Dauer der Behandlung\/Wundheilung (RIS: 19,9), w\u00e4hrend leichte oder schwere unerw\u00fcnschte Ereignisse (RIS: 10,7 beziehungsweise 9,3) als weniger wichtig angesehen wurden. Die Patienten bevorzugten Tabletten gegen\u00fcber subkutanen Injektionen und lehnten eine Operation mit prim\u00e4rem Verschluss ab. Die Pr\u00e4ferenzen unterschieden sich deutlich je nach Alter und den betroffenen K\u00f6rperregionen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerung<\/jats:title><jats:p>Die Kenntnis der Patientenpr\u00e4ferenzen ist f\u00fcr eine patientenzentrierte Versorgung bei HS von wesentlicher Bedeutung.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.14886_g","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T21:23:34Z","timestamp":1668633814000},"page":"1441-1454","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patientenpr\u00e4ferenzen bei Hidradenitis suppurativa (APProach\u2010HS): ein \u201cDiscrete\u2010Choice\u201d\u2010Experiment"],"prefix":"10.1111","volume":"20","author":[{"given":"Kristin","family":"Faverio","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Phlebologie Vivantes Klinikum im Friedrichshain  Berlin 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